Metadata
| Name | Subarachnoid haemorrhage (Subarach) |
| Category | Cardiovascular |
| Sex | |
| Adult | Yes |
| UUID | 2ea6d6fa-b07b-4cd2-aab2-5c7b0d0a01e3 |
| Definition | Bleeding into the intracranial or spinal subarachnoid space, most resulting from intercranial aneurysm rupture. |
Ontologies
| Disease Ontology (DOID) | DOID_0080964 |
| GWAS Catalogue | EFO_0000713 |
| MeSH | D013345 |
| SNOMED-CT | 21454007 |
| FinnGen | I9_SAH |
Key Summary Statistics
Cases from any source
| Total | 2129 |
| Female (%) | 1284 (60%) |
| Male (%) | 845 (40%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 27.82 (24.27,31.36) |
| Male | 24.08 (20.48,27.67) |
Incidence stratified by sex
| Female | 1.83 (1.48,2.18) |
| Male | 1.79 (1.41,2.17) |
Incidence stratified by age
| Ages 40-44 | 1.01 (0.38,1.63) |
| Ages 45-49 | 1.63 (0.95,2.32) |
| Ages 50-54 | 1.59 (0.96,2.21) |
| Ages 55-59 | 2.14 (1.48,2.79) |
| Ages 60-64 | 1.62 (1.13,2.11) |
| Ages 65-69 | 2.47 (1.78,3.16) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 21 (17,26) | 35 (31,40) | 42 (38,47) |
| CALIBER | 19 (18,20) | 31 (30,33) | 43 (41,45) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 17(9,29) | 27(19,37) | 30(22,38) |
| Low | 20(11,34) | 28(20,39) | 43(34,53) |
| Medium | 18(10,30) | 36(26,48) | 42(33,52) |
| High | 21(12,33) | 35(25,46) | 50(40,61) |
| Most deprived | 28(19,40) | 50(39,63) | 49(39,62) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 22(17,28) | 36(31,42) | 42(38,47) |
| Scotland | 22(11,40) | 40(28,56) | 33(23,45) |
| Wales | 10(2,29) | 14(5,28) | 57(40,77) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.89 (0.65, 1.23) | 0.488 |
| BMI | obese | 1.16 (0.82, 1.63) | 0.404 |
| BMI | underweight | 0 (0, Inf) | 0.989 |
| smoking | previous | 1.75 (1.31, 2.35) | 0.000182 |
| smoking | current | 2.37 (1.58, 3.55) | 3.07e-05 |
| hypertension | yes | 1 (0.74, 1.36) | 0.997 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1086 | subarachnoid haemorrhage |
| 41202 | Diagnoses - main ICD10 | I60 | Subarachnoid haemorrhage |
| 41202 | Diagnoses - main ICD10 | I69.0 | Sequelae of subarachnoid haemorrhage |
| 41204 | Diagnoses - secondary ICD10 | I60 | Subarachnoid haemorrhage |
| 41204 | Diagnoses - secondary ICD10 | I69.0 | Sequelae of subarachnoid haemorrhage |
| 40001 | Underlying (primary) cause of death: ICD10 | I60 | Subarachnoid haemorrhage |
| 40001 | Underlying (primary) cause of death: ICD10 | I69.0 | Sequelae of subarachnoid haemorrhage |
| 40002 | Contributory (secondary) causes of death: ICD10 | I60 | Subarachnoid haemorrhage |
| 40002 | Contributory (secondary) causes of death: ICD10 | I69.0 | Sequelae of subarachnoid haemorrhage |
| 42040 | GP clinical event records | G600.00 | Ruptured berry aneurysm |
| 42040 | GP clinical event records | G601.00 | Subarachnoid haemorrhage from carotid siphon and bifurcation |
| 42040 | GP clinical event records | G602.00 | Subarachnoid haemorrhage from middle cerebral artery |
| 42040 | GP clinical event records | G603.00 | Subarachnoid haemorrhage from anterior communicating artery |
| 42040 | GP clinical event records | G604.00 | Subarachnoid haemorrhage from posterior communicating artery |
| 42040 | GP clinical event records | G605.00 | Subarachnoid haemorrhage from basilar artery |
| 42040 | GP clinical event records | G606.00 | Subarachnoid haemorrhage from vertebral artery |
| 42040 | GP clinical event records | G60..00 | Subarachnoid haemorrhage |
| 42040 | GP clinical event records | G60X.00 | Subarachnoid haemorrh from intracranial artery, unspecif |
| 42040 | GP clinical event records | G60z.00 | Subarachnoid haemorrhage NOS |
| 42040 | GP clinical event records | G680.00 | Sequelae of subarachnoid haemorrhage |
| 42040 | GP clinical event records | Gyu6000 | [X]Subarachnoid haemorrhage from other intracranial arteries |
| 42040 | GP clinical event records | Gyu6100 | [X]Other subarachnoid haemorrhage |
| 42040 | GP clinical event records | Gyu6E00 | [X]Subarachnoid haemorrh from intracranial artery, unspecif |
| 42040 | GP clinical event records | Xa1uW | Subarachnoid haemorrhage |