| Name |
Thalassaemia trait (thal_trait) |
| Category |
Haematological or immunological |
| Sex |
|
| Adult |
Yes |
| UUID |
2089d3e0-f3b8-42d6-bb2d-da68cc3e0c7c |
| Definition |
The presence of a faulty gene that causes thalassaemia, but not the condition itself. |
Cases from any source
| Total |
473 |
| Female (%) |
288 (61%) |
| Male (%) |
185 (39%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
10.73 (8.52,12.93) |
| Male |
8.82 (6.64,11.0) |
Incidence stratified by sex
| Female |
0.33 (0.18,0.48) |
| Male |
0.4 (0.22,0.58) |
Incidence stratified by age
| Ages 40-44 |
0.5 (0.06,0.95) |
| Ages 45-49 |
0.59 (0.18,1.01) |
| Ages 50-54 |
0.63 (0.24,1.03) |
| Ages 55-59 |
0.31 (0.06,0.56) |
| Ages 60-64 |
0.19 (0.02,0.36) |
| Ages 65-69 |
0.2 (0.0,0.4) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
17 (13,21) |
12 (10,15) |
8 (7,10) |
| CALIBER |
17 (16,18) |
14 (12,15) |
9 (8,10) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
11(5,21) |
7(3,13) |
5(3,10) |
| Low |
5(1,14) |
5(2,10) |
4(2,8) |
| Medium |
15(8,27) |
7(3,13) |
9(5,15) |
| High |
22(14,34) |
20(13,30) |
12(7,19) |
| Most deprived |
25(16,36) |
23(15,32) |
12(7,19) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
17(13,22) |
13(10,17) |
9(7,12) |
| Scotland |
10(3,23) |
7(3,16) |
5(1,11) |
| Wales |
19(7,41) |
13(5,27) |
6(2,15) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
D56.3 |
Thalassaemia trait |
| 41204 |
Diagnoses - secondary ICD10 |
D56.3 |
Thalassaemia trait |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D56.3 |
Thalassaemia trait |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D56.3 |
Thalassaemia trait |
| 42040 |
GP clinical event records |
D104100 |
Thalassaemia minor NEC |
| 42040 |
GP clinical event records |
D104400 |
Alpha trait thalassaemia |
| 42040 |
GP clinical event records |
D104500 |
Beta trait thalassaemia |
| 42040 |
GP clinical event records |
D104800 |
Beta minor thalassaemia |