Metadata

Name Hypo or hyperthyroidism (thyroid)
Category Endocrine
Sex
Adult Yes
UUID 1cb52ac9-3dec-4abd-bf9d-a59634a7fad9

Ontologies

GWAS Catalogue EFO_1000627

Key Summary Statistics

Cases from any source

Total 43851
Female (%) 35224 (80%)
Male (%) 8627 (20%)

Year first recorded

thyroid year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced thyroid cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of thyroid

Baseline prevalence stratified by sex

Female 1103.92 (1082.83,1125.01)
Male 278.45 (266.38,290.51)

Incidence stratified by sex

Female 28.92 (27.43,30.41)
Male 11.31 (10.34,12.28)

Incidence stratified by age

Ages 40-44 16.76 (14.16,19.37)
Ages 45-49 18.25 (15.91,20.6)
Ages 50-54 21.41 (19.04,23.78)
Ages 55-59 19.87 (17.79,21.95)
Ages 60-64 22.82 (20.89,24.74)
Ages 65-69 20.83 (18.72,22.94)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB thyroid prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 461 (441,482) 685 (666,704) 874 (855,893)
CALIBER 468 (462,474) 710 (702,718) 943 (934,953)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 391(348,438) 617(577,659) 792(754,832)
Low 470(422,521) 618(577,660) 848(809,889)
Medium 404(361,450) 677(635,721) 847(806,888)
High 475(432,521) 724(681,770) 905(862,950)
Most deprived 534(491,580) 784(738,831) 1001(953,1050)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 442(420,464) 662(641,684) 851(830,872)
Scotland 505(447,569) 722(669,778) 932(877,990)
Wales 600(518,691) 848(774,928) 1023(950,1100)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=144148, Events=6009

Factor Level Hazard Ratio P value
BMI overweight 11.38 (9.13, 14.19) 5.4799999999999994e-104
BMI obese 105.81 (85.37, 131.15) 0.0
BMI underweight 0.72 (0.1, 5.2) 0.748
smoking previous 1.24 (1.17, 1.31) 3.31e-14
smoking current 1.26 (1.16, 1.36) 8.24e-08
hypertension yes 2.26 (2.13, 2.39) 1.3899999999999998e-180

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1225 hyperthyroidism/thyrotoxicosis
20002 Non-cancer illness code, self-reported 1428 thyroiditis
20002 Non-cancer illness code, self-reported 1226 hypothyroidism/myxoedema
20002 Non-cancer illness code, self-reported 1522 grave’s disease
41202 Diagnoses - main ICD10 E03.5 Myxoedema coma
41202 Diagnoses - main ICD10 E03.8 Other specified hypothyroidism
41202 Diagnoses - main ICD10 E03.9 Hypothyroidism, unspecified
41202 Diagnoses - main ICD10 E05.0 Thyrotoxicosis with diffuse goitre
41202 Diagnoses - main ICD10 E05.1 Thyrotoxicosis with toxic single thyroid nodule
41202 Diagnoses - main ICD10 E05.2 Thyrotoxicosis with toxic multinodular goitre
41202 Diagnoses - main ICD10 E05.5 Thyroid crisis or storm
41202 Diagnoses - main ICD10 E05.8 Other thyrotoxicosis
41202 Diagnoses - main ICD10 E05.9 Thyrotoxicosis, unspecified
41202 Diagnoses - main ICD10 E06.2 Chronic thyroiditis with transient thyrotoxicosis
41202 Diagnoses - main ICD10 E06.3 Autoimmune thyroiditis
41202 Diagnoses - main ICD10 E06.5 Other chronic thyroiditis
41202 Diagnoses - main ICD10 E06.9 Thyroiditis, unspecified
41202 Diagnoses - main ICD10 H06.2 Dysthyroid exophthalmos
41204 Diagnoses - secondary ICD10 E03.5 Myxoedema coma
41204 Diagnoses - secondary ICD10 E03.8 Other specified hypothyroidism
41204 Diagnoses - secondary ICD10 E03.9 Hypothyroidism, unspecified
41204 Diagnoses - secondary ICD10 E05.0 Thyrotoxicosis with diffuse goitre
41204 Diagnoses - secondary ICD10 E05.1 Thyrotoxicosis with toxic single thyroid nodule
41204 Diagnoses - secondary ICD10 E05.2 Thyrotoxicosis with toxic multinodular goitre
41204 Diagnoses - secondary ICD10 E05.5 Thyroid crisis or storm
41204 Diagnoses - secondary ICD10 E05.8 Other thyrotoxicosis
41204 Diagnoses - secondary ICD10 E05.9 Thyrotoxicosis, unspecified
41204 Diagnoses - secondary ICD10 E06.2 Chronic thyroiditis with transient thyrotoxicosis
41204 Diagnoses - secondary ICD10 E06.3 Autoimmune thyroiditis
41204 Diagnoses - secondary ICD10 E06.5 Other chronic thyroiditis
41204 Diagnoses - secondary ICD10 E06.9 Thyroiditis, unspecified
41204 Diagnoses - secondary ICD10 H06.2 Dysthyroid exophthalmos
40001 Underlying (primary) cause of death: ICD10 E03.5 Myxoedema coma
40001 Underlying (primary) cause of death: ICD10 E03.8 Other specified hypothyroidism
40001 Underlying (primary) cause of death: ICD10 E03.9 Hypothyroidism, unspecified
40001 Underlying (primary) cause of death: ICD10 E05.0 Thyrotoxicosis with diffuse goitre
40001 Underlying (primary) cause of death: ICD10 E05.1 Thyrotoxicosis with toxic single thyroid nodule
40001 Underlying (primary) cause of death: ICD10 E05.2 Thyrotoxicosis with toxic multinodular goitre
40001 Underlying (primary) cause of death: ICD10 E05.5 Thyroid crisis or storm
40001 Underlying (primary) cause of death: ICD10 E05.8 Other thyrotoxicosis
40001 Underlying (primary) cause of death: ICD10 E05.9 Thyrotoxicosis, unspecified
40001 Underlying (primary) cause of death: ICD10 E06.2 Chronic thyroiditis with transient thyrotoxicosis
40001 Underlying (primary) cause of death: ICD10 E06.3 Autoimmune thyroiditis
40001 Underlying (primary) cause of death: ICD10 E06.5 Other chronic thyroiditis
40001 Underlying (primary) cause of death: ICD10 E06.9 Thyroiditis, unspecified
40001 Underlying (primary) cause of death: ICD10 H06.2 Dysthyroid exophthalmos
40002 Contributory (secondary) causes of death: ICD10 E03.5 Myxoedema coma
40002 Contributory (secondary) causes of death: ICD10 E03.8 Other specified hypothyroidism
40002 Contributory (secondary) causes of death: ICD10 E03.9 Hypothyroidism, unspecified
40002 Contributory (secondary) causes of death: ICD10 E05.0 Thyrotoxicosis with diffuse goitre
40002 Contributory (secondary) causes of death: ICD10 E05.1 Thyrotoxicosis with toxic single thyroid nodule
40002 Contributory (secondary) causes of death: ICD10 E05.2 Thyrotoxicosis with toxic multinodular goitre
40002 Contributory (secondary) causes of death: ICD10 E05.5 Thyroid crisis or storm
40002 Contributory (secondary) causes of death: ICD10 E05.8 Other thyrotoxicosis
40002 Contributory (secondary) causes of death: ICD10 E05.9 Thyrotoxicosis, unspecified
40002 Contributory (secondary) causes of death: ICD10 E06.2 Chronic thyroiditis with transient thyrotoxicosis
40002 Contributory (secondary) causes of death: ICD10 E06.3 Autoimmune thyroiditis
40002 Contributory (secondary) causes of death: ICD10 E06.5 Other chronic thyroiditis
40002 Contributory (secondary) causes of death: ICD10 E06.9 Thyroiditis, unspecified
40002 Contributory (secondary) causes of death: ICD10 H06.2 Dysthyroid exophthalmos
42040 GP clinical event records 1431.00 H/O: hyperthyroidism
42040 GP clinical event records 1431.11 H/O: thyrotoxicosis
42040 GP clinical event records 143..11 H/O: thyroid disorder
42040 GP clinical event records 1432.00 H/O: hypothyroidism
42040 GP clinical event records 1433.00 H/O: thyroid disorder NOS
42040 GP clinical event records 212P.00 Hyperthyroidism resolved
42040 GP clinical event records 66B4.00 Thyroid eye disease
42040 GP clinical event records 66B..00 Thyroid disease monitoring
42040 GP clinical event records 66BB.00 Hypothyroidism annual review
42040 GP clinical event records 66BZ.00 Thyroid disease monitoring NOS
42040 GP clinical event records 8CR5.00 Hypothyroidism clinical management plan
42040 GP clinical event records 9Oj0.00 Hypothyroidism monitoring first letter
42040 GP clinical event records 9Oj1.00 Hypothyroidism monitoring second letter
42040 GP clinical event records 9Oj2.00 Hypothyroidism monitoring third letter
42040 GP clinical event records 9Oj3.00 Hypothyroidism monitoring verbal invite
42040 GP clinical event records 9Oj4.00 Hypothyroidism monitoring telephone invitation
42040 GP clinical event records 9Oj..00 Hypothyroidism monitoring administration
42040 GP clinical event records C020000 Toxic diffuse goitre with no crisis
42040 GP clinical event records C020100 Toxic diffuse goitre with crisis
42040 GP clinical event records C020200 Thyroid-associated dermopathy
42040 GP clinical event records C020.00 Toxic diffuse goitre
42040 GP clinical event records C020.11 Basedow’s disease
42040 GP clinical event records C020.12 Graves’ disease
42040 GP clinical event records C020z00 Toxic diffuse goitre NOS
42040 GP clinical event records C021000 Toxic uninodular goitre with no crisis
42040 GP clinical event records C021.00 Toxic uninodular goitre
42040 GP clinical event records C021z00 Toxic uninodular goitre NOS
42040 GP clinical event records C022000 Toxic multinodular goitre with no crisis
42040 GP clinical event records C022.00 Toxic multinodular goitre
42040 GP clinical event records C022z00 Toxic multinodular goitre NOS
42040 GP clinical event records C023000 Toxic nodular goitre unspecified with no crisis
42040 GP clinical event records C023100 Toxic nodular goitre unspecified with crisis
42040 GP clinical event records C023.00 Toxic nodular goitre unspecified
42040 GP clinical event records C023z00 Toxic nodular goitre NOS
42040 GP clinical event records C02..00 Thyrotoxicosis
42040 GP clinical event records C02..11 Hyperthyroidism
42040 GP clinical event records C02..12 Toxic goitre
42040 GP clinical event records C02y000 Thyrotoxicosis of other specified origin with no crisis
42040 GP clinical event records C02y100 Thyrotoxicosis of other specified origin with crisis
42040 GP clinical event records C02y300 Thyroid crisis
42040 GP clinical event records C02y.00 Thyrotoxicosis of other specified origin
42040 GP clinical event records C02yz00 Thyrotoxicosis of other specified origin NOS
42040 GP clinical event records C02z000 Thyrotoxicosis without mention of goitre or cause no crisis
42040 GP clinical event records C02z100 Thyrotoxicosis without mention of goitre, cause with crisis
42040 GP clinical event records C02z.00 Thyrotoxicosis without mention of goitre or other cause
42040 GP clinical event records C02zz00 Thyrotoxicosis NOS
42040 GP clinical event records C040.00 Postsurgical hypothyroidism
42040 GP clinical event records C040.11 Post ablative hypothyroidism
42040 GP clinical event records C041000 Irradiation hypothyroidism
42040 GP clinical event records C041.00 Other postablative hypothyroidism
42040 GP clinical event records C041z00 Postablative hypothyroidism NOS
42040 GP clinical event records C043.00 Other iatrogenic hypothyroidism
42040 GP clinical event records C043z00 Iatrogenic hypothyroidism NOS
42040 GP clinical event records C046.00 Autoimmune myxoedema
42040 GP clinical event records C04..00 Acquired hypothyroidism
42040 GP clinical event records C04..11 Myxoedema
42040 GP clinical event records C04..12 Thyroid deficiency
42040 GP clinical event records C04..13 Hypothyroidism
42040 GP clinical event records C04y.00 Other acquired hypothyroidism
42040 GP clinical event records C04z000 Premature puberty due to hypothyroidism
42040 GP clinical event records C04z100 Myxoedema coma
42040 GP clinical event records C04z.00 Hypothyroidism NOS
42040 GP clinical event records C04z.11 Pretibial myxoedema - hypothyroid
42040 GP clinical event records C04z.12 Thyroid insufficiency
42040 GP clinical event records C04z.13 Hypothyroid goitre, acquired
42040 GP clinical event records C052.00 Chronic lymphocytic thyroiditis
42040 GP clinical event records C052.11 Autoimmune thyroiditis
42040 GP clinical event records C052.12 Hashimoto’s disease
42040 GP clinical event records C053.00 Chronic fibrous thyroiditis
42040 GP clinical event records C05..00 Thyroiditis
42040 GP clinical event records C05y400 Chronic thyroiditis with transient thyrotoxicosis
42040 GP clinical event records C05y.00 Other and unspecified chronic thyroiditis
42040 GP clinical event records C05z.00 Thyroiditis NOS
42040 GP clinical event records C06y100 Thyroid atrophy
42040 GP clinical event records C134300 TSH - thyroid-stimulating hormone deficiency
42040 GP clinical event records Cyu1100 [X]Other sp cified hypothyroidism
42040 GP clinical event records Cyu1300 [X]Other thyrotoxicosis
42040 GP clinical event records Cyu1400 [X]Other chronic thyroiditis
42040 GP clinical event records F11x500 Cerebral degeneration due to myxoedema
42040 GP clinical event records F381400 Myasthenic syndrome due to hypothyroidism
42040 GP clinical event records F381600 Myasthenic syndrome due to thyrotoxicosis
42040 GP clinical event records F395300 Myopathy due to myxoedema
42040 GP clinical event records F395400 Myopathy due to thyrotoxicosis
42040 GP clinical event records F4G2000 Thyrotoxic exophthalmos
42040 GP clinical event records FyuBD00 [X]Dysthyroid exophthalmos
42040 GP clinical event records G557500 Thyrotoxic heart disease
42040 GP clinical event records XaJuE Hypothyroidism monitoring administration
42040 GP clinical event records XaOjl Hypothyroidism annual review
42040 GP clinical event records XE108 Acquired hypothyroidism
42040 GP clinical event records XE108 Acquired hypothyroidism
42040 GP clinical event records XaMFm Hypothyroidism monitoring telephone invitation
42040 GP clinical event records XaJYj Hypothyroidism clinical management plan
42040 GP clinical event records XE106 Thyrotoxicosis of other specified origin
42040 GP clinical event records XaKbz Hypothyroidism monitoring verbal invite
42040 GP clinical event records XE104 Thyrotoxicosis
42040 GP clinical event records X005I Myxoedema coma
42040 GP clinical event records XE10D Chronic fibrous thyroiditis
42040 GP clinical event records XS29G Thyroid eye disease
42040 GP clinical event records XE0q3 H/O: endocrine disorder
42040 GP clinical event records XaJuN Hypothyroidism monitoring second letter
42040 GP clinical event records XaJuM Hypothyroidism monitoring first letter
42040 GP clinical event records XaKcQ Hyperthyroidism resolved
42040 GP clinical event records X40OO Thyroid-associated dermopathy
42040 GP clinical event records X40Hd Chronic thyroiditis with transient thyrotoxicosis
42040 GP clinical event records XE10A Hypothyroidism NOS
42040 GP clinical event records XaJuO Hypothyroidism monitoring third letter
42040 GP clinical event records XE105 Toxic diffuse goitre
42040 GP clinical event records X40H3 Thyroid crisis