Metadata
| Name | Thyroiditis unspecified (thyroid_nos) |
| Category | Endocrine |
| Sex | |
| Adult | Yes |
| UUID | dd7caba8-4df6-43dd-928e-2aec36585cd6 |
Ontologies
| Disease Ontology (DOID) | DOID_7166 |
| GWAS Catalogue | EFO_1000627 |
| MeSH | D013966 |
| SNOMED-CT | 82119001 |
| FinnGen | THYROIDITIS |
Key Summary Statistics
Cases from any source
| Total | 5150 |
| Female (%) | 4263 (83%) |
| Male (%) | 887 (17%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 280.08 (268.97,291.18) |
| Male | 70.0 (63.88,76.11) |
Incidence stratified by sex
| Female | 1.47 (1.15,1.79) |
| Male | 0.7 (0.46,0.94) |
Incidence stratified by age
| Ages 40-44 | 1.42 (0.68,2.17) |
| Ages 45-49 | 1.66 (0.96,2.35) |
| Ages 50-54 | 1.09 (0.57,1.61) |
| Ages 55-59 | 0.85 (0.43,1.26) |
| Ages 60-64 | 1.22 (0.79,1.65) |
| Ages 65-69 | 0.72 (0.34,1.1) |
Period prevalence
Methods
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 115 (105,125) | 172 (163,182) | 224 (214,233) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 122(98,149) | 173(152,196) | 204(185,225) |
| Low | 129(105,158) | 151(131,173) | 213(194,234) |
| Medium | 103(82,127) | 178(156,201) | 225(205,247) |
| High | 108(88,131) | 179(158,202) | 225(203,247) |
| Most deprived | 116(96,138) | 182(161,206) | 258(234,284) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 91(81,101) | 135(126,145) | 182(172,191) |
| Scotland | 179(145,218) | 293(259,329) | 375(340,412) |
| Wales | 270(216,334) | 340(294,391) | 430(384,481) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=144148, Events=6009
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 11.38 (9.13, 14.19) | 5.4799999999999994e-104 |
| BMI | obese | 105.81 (85.37, 131.15) | 0.0 |
| BMI | underweight | 0.72 (0.1, 5.2) | 0.748 |
| smoking | previous | 1.24 (1.17, 1.31) | 3.31e-14 |
| smoking | current | 1.26 (1.16, 1.36) | 8.24e-08 |
| hypertension | yes | 2.26 (2.13, 2.39) | 1.3899999999999998e-180 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1428 | thyroiditis |
| 41202 | Diagnoses - main ICD10 | E06.3 | Autoimmune thyroiditis |
| 41202 | Diagnoses - main ICD10 | E06.5 | Other chronic thyroiditis |
| 41202 | Diagnoses - main ICD10 | E06.9 | Thyroiditis, unspecified |
| 41204 | Diagnoses - secondary ICD10 | E06.3 | Autoimmune thyroiditis |
| 41204 | Diagnoses - secondary ICD10 | E06.5 | Other chronic thyroiditis |
| 41204 | Diagnoses - secondary ICD10 | E06.9 | Thyroiditis, unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | E06.3 | Autoimmune thyroiditis |
| 40001 | Underlying (primary) cause of death: ICD10 | E06.5 | Other chronic thyroiditis |
| 40001 | Underlying (primary) cause of death: ICD10 | E06.9 | Thyroiditis, unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | E06.3 | Autoimmune thyroiditis |
| 40002 | Contributory (secondary) causes of death: ICD10 | E06.5 | Other chronic thyroiditis |
| 40002 | Contributory (secondary) causes of death: ICD10 | E06.9 | Thyroiditis, unspecified |
| 42040 | GP clinical event records | 143..11 | H/O: thyroid disorder |
| 42040 | GP clinical event records | 1433.00 | H/O: thyroid disorder NOS |
| 42040 | GP clinical event records | 66B4.00 | Thyroid eye disease |
| 42040 | GP clinical event records | 66B..00 | Thyroid disease monitoring |
| 42040 | GP clinical event records | 66BZ.00 | Thyroid disease monitoring NOS |
| 42040 | GP clinical event records | C052.00 | Chronic lymphocytic thyroiditis |
| 42040 | GP clinical event records | C052.11 | Autoimmune thyroiditis |
| 42040 | GP clinical event records | C053.00 | Chronic fibrous thyroiditis |
| 42040 | GP clinical event records | C05..00 | Thyroiditis |
| 42040 | GP clinical event records | C05y400 | Chronic thyroiditis with transient thyrotoxicosis |
| 42040 | GP clinical event records | C05y.00 | Other and unspecified chronic thyroiditis |
| 42040 | GP clinical event records | C05z.00 | Thyroiditis NOS |
| 42040 | GP clinical event records | Cyu1400 | [X]Other chronic thyroiditis |
| 42040 | GP clinical event records | XE10D | Chronic fibrous thyroiditis |
| 42040 | GP clinical event records | XS29G | Thyroid eye disease |
| 42040 | GP clinical event records | XE0q3 | H/O: endocrine disorder |
| 42040 | GP clinical event records | X40OO | Thyroid-associated dermopathy |