Transient ischaemic attack

Metadata

Name	Transient ischaemic attack (TIA)
Category	Cardiovascular
Sex
Adult	Yes
UUID	79b2c4bb-c97a-4e1e-817e-ef81e83193fb
Definition	A transient ischaemic attack (TIA) or “mini stroke” is caused by a temporary disruption in the blood supply to part of the brain.

Ontologies

Disease Ontology (DOID)	DOID_224
GWAS Catalogue	EFO_0003764
MeSH	D002546
SNOMED-CT	266257000
FinnGen	G6_TIA

Key Summary Statistics

Cases from any source

Total	11006
Female (%)	4738 (43%)
Male (%)	6268 (57%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	80.04 (74.04,86.03)
Male	137.89 (129.34,146.45)

Incidence stratified by sex

Female	10.05 (9.22,10.88)
Male	14.7 (13.6,15.8)

Incidence stratified by age

Ages 40-44	2.42 (1.45,3.38)
Ages 45-49	4.31 (3.2,5.42)
Ages 50-54	6.11 (4.89,7.34)
Ages 55-59	9.93 (8.51,11.34)
Ages 60-64	16.35 (14.78,17.92)
Ages 65-69	24.2 (22.01,26.39)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	33 (27,39)	96 (88,104)	246 (236,256)
CALIBER	40 (38,42)	119 (116,122)	305 (300,311)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	20(11,33)	73(59,90)	205(185,226)
Low	23(13,37)	85(70,103)	227(207,250)
Medium	27(16,41)	82(67,100)	255(233,279)
High	31(21,46)	109(92,129)	230(208,254)
Most deprived	52(39,68)	128(110,149)	324(296,354)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	29(24,36)	86(78,95)	222(211,233)
Scotland	47(29,70)	119(97,144)	325(291,361)
Wales	48(26,80)	152(120,190)	374(330,423)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154060, Events=218

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.65, 1.23)	0.488
BMI	obese	1.16 (0.82, 1.63)	0.404
BMI	underweight	0 (0, Inf)	0.989
smoking	previous	1.75 (1.31, 2.35)	0.000182
smoking	current	2.37 (1.58, 3.55)	3.07e-05
hypertension	yes	1 (0.74, 1.36)	0.997

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1082	transient ischaemic attack (tia)
41202	Diagnoses - main ICD10	G45.0	Vertebro-basilar artery syndrome
41202	Diagnoses - main ICD10	G45.1	Carotid artery syndrome (hemispheric)
41202	Diagnoses - main ICD10	G45.2	Multiple and bilateral precerebral artery syndromes
41202	Diagnoses - main ICD10	G45.3	Amaurosis fugax
41202	Diagnoses - main ICD10	G45.4	Transient global amnesia
41202	Diagnoses - main ICD10	G45.8	Other transient cerebral ischaemic attacks and related syndromes
41202	Diagnoses - main ICD10	G45.9	Transient cerebral ischaemic attack, unspecified
41202	Diagnoses - main ICD10	G46.0	Middle cerebral artery syndrome
41202	Diagnoses - main ICD10	G46.1	Anterior cerebral artery syndrome
41202	Diagnoses - main ICD10	G46.2	Posterior cerebral artery syndrome
41202	Diagnoses - main ICD10	I65	Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
41202	Diagnoses - main ICD10	I66	Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
41204	Diagnoses - secondary ICD10	G45.0	Vertebro-basilar artery syndrome
41204	Diagnoses - secondary ICD10	G45.1	Carotid artery syndrome (hemispheric)
41204	Diagnoses - secondary ICD10	G45.2	Multiple and bilateral precerebral artery syndromes
41204	Diagnoses - secondary ICD10	G45.3	Amaurosis fugax
41204	Diagnoses - secondary ICD10	G45.4	Transient global amnesia
41204	Diagnoses - secondary ICD10	G45.8	Other transient cerebral ischaemic attacks and related syndromes
41204	Diagnoses - secondary ICD10	G45.9	Transient cerebral ischaemic attack, unspecified
41204	Diagnoses - secondary ICD10	G46.0	Middle cerebral artery syndrome
41204	Diagnoses - secondary ICD10	G46.1	Anterior cerebral artery syndrome
41204	Diagnoses - secondary ICD10	G46.2	Posterior cerebral artery syndrome
41204	Diagnoses - secondary ICD10	I65	Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
41204	Diagnoses - secondary ICD10	I66	Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
40001	Underlying (primary) cause of death: ICD10	G45.0	Vertebro-basilar artery syndrome
40001	Underlying (primary) cause of death: ICD10	G45.1	Carotid artery syndrome (hemispheric)
40001	Underlying (primary) cause of death: ICD10	G45.2	Multiple and bilateral precerebral artery syndromes
40001	Underlying (primary) cause of death: ICD10	G45.3	Amaurosis fugax
40001	Underlying (primary) cause of death: ICD10	G45.4	Transient global amnesia
40001	Underlying (primary) cause of death: ICD10	G45.8	Other transient cerebral ischaemic attacks and related syndromes
40001	Underlying (primary) cause of death: ICD10	G45.9	Transient cerebral ischaemic attack, unspecified
40001	Underlying (primary) cause of death: ICD10	G46.0	Middle cerebral artery syndrome
40001	Underlying (primary) cause of death: ICD10	G46.1	Anterior cerebral artery syndrome
40001	Underlying (primary) cause of death: ICD10	G46.2	Posterior cerebral artery syndrome
40001	Underlying (primary) cause of death: ICD10	I65	Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
40001	Underlying (primary) cause of death: ICD10	I66	Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
40002	Contributory (secondary) causes of death: ICD10	G45.0	Vertebro-basilar artery syndrome
40002	Contributory (secondary) causes of death: ICD10	G45.1	Carotid artery syndrome (hemispheric)
40002	Contributory (secondary) causes of death: ICD10	G45.2	Multiple and bilateral precerebral artery syndromes
40002	Contributory (secondary) causes of death: ICD10	G45.3	Amaurosis fugax
40002	Contributory (secondary) causes of death: ICD10	G45.4	Transient global amnesia
40002	Contributory (secondary) causes of death: ICD10	G45.8	Other transient cerebral ischaemic attacks and related syndromes
40002	Contributory (secondary) causes of death: ICD10	G45.9	Transient cerebral ischaemic attack, unspecified
40002	Contributory (secondary) causes of death: ICD10	G46.0	Middle cerebral artery syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.1	Anterior cerebral artery syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.2	Posterior cerebral artery syndrome
40002	Contributory (secondary) causes of death: ICD10	I65	Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
40002	Contributory (secondary) causes of death: ICD10	I66	Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
42040	GP clinical event records	14AB000	H/O amaurosis fugax
42040	GP clinical event records	14AB.00	H/O: TIA
42040	GP clinical event records	1B1S.00	Transient global amnesia
42040	GP clinical event records	8CRB.00	Transient ischaemic attack clinical management plan
42040	GP clinical event records	F423600	Amaurosis fugax
42040	GP clinical event records	Fyu5500	[X]Other transnt cerebral ischaemic attacks+related syndroms
42040	GP clinical event records	G650.11	Insufficiency - basilar artery
42040	GP clinical event records	G655.00	Transient global amnesia
42040	GP clinical event records	G656.00	Vertebrobasilar insufficiency
42040	GP clinical event records	G657.00	Carotid territory transient ischaemic attack
42040	GP clinical event records	G65..00	Transient cerebral ischaemia
42040	GP clinical event records	G65..12	Transient ischaemic attack
42040	GP clinical event records	G65..13	Vertebro-basilar insufficiency
42040	GP clinical event records	G65y.00	Other transient cerebral ischaemia
42040	GP clinical event records	G65z100	Intermittent cerebral ischaemia
42040	GP clinical event records	G65z.00	Transient cerebral ischaemia NOS
42040	GP clinical event records	G65zz00	Transient cerebral ischaemia NOS
42040	GP clinical event records	Z7CE700	Transient global amnesia
42040	GP clinical event records	Z7CE711	TGA - Transient global amnesia
42040	GP clinical event records	ZV12D00	[V]Personal history of transient ischaemic attack
42040	GP clinical event records	X00DW	Vertebrobasilar insufficiency
42040	GP clinical event records	XaX16	[V]Personal history of transient ischaemic attack
42040	GP clinical event records	X00E2	Transient global amnesia
42040	GP clinical event records	XaQve	Transient ischaemic attack clinical management plan
42040	GP clinical event records	X00E2	Transient global amnesia
42040	GP clinical event records	X00DU	Carotid territory transient ischaemic attack
42040	GP clinical event records	G65z.	Transient cerebral ischaemia NOS
42040	GP clinical event records	XaZIY	H/O amaurosis fugax