Tubulo-interstitial nephritis

Metadata

Name	Tubulo-interstitial nephritis (TIN)
Category	Genitourinary
Sex
Adult	Yes
UUID	60176c5a-7cf6-4676-a048-263fa47d4c33
Definition	Primary inflammation of tubules in the interstitial tissue of the kidney.

Ontologies

Disease Ontology (DOID)	DOID_1063
MeSH	D009395
SNOMED-CT	428255004
FinnGen	N14_TUBULOINTNEPHRNAS

Key Summary Statistics

Cases from any source

Total	2561
Female (%)	1745 (68%)
Male (%)	816 (32%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	18.62 (15.72,21.53)
Male	8.54 (6.4,10.68)

Incidence stratified by sex

Female	2.39 (1.99,2.8)
Male	1.37 (1.04,1.7)

Incidence stratified by age

Ages 40-44	1.31 (0.6,2.02)
Ages 45-49	1.78 (1.07,2.5)
Ages 50-54	2.09 (1.38,2.81)
Ages 55-59	1.87 (1.26,2.49)
Ages 60-64	2.08 (1.52,2.63)
Ages 65-69	2.06 (1.43,2.69)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	24 (20,29)	24 (21,28)	22 (19,26)
CALIBER	31 (30,33)	28 (26,29)	28 (26,30)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	17(9,28)	23(15,33)	22(16,29)
Low	12(5,22)	18(12,27)	19(14,26)
Medium	16(9,28)	25(17,35)	17(12,25)
High	29(19,42)	24(16,33)	24(18,33)
Most deprived	41(29,55)	31(23,42)	30(22,40)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	24(19,30)	25(21,30)	21(18,25)
Scotland	23(12,39)	25(16,37)	20(12,30)
Wales	25(11,49)	14(5,28)	35(23,52)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.96 (0.75, 1.22)	0.716
BMI	obese	1.36 (1.06, 1.76)	0.0167
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.37 (1.1, 1.7)	0.00438
smoking	current	2.14 (1.6, 2.85)	2.26e-07
hypertension	yes	1.88 (1.53, 2.31)	1.47e-09

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1515	pyelonephritis
41202	Diagnoses - main ICD10	N12	Tubulo-interstitial nephritis, not specified as acute or chronic
41202	Diagnoses - main ICD10	N14.0	Analgesic nephropathy
41202	Diagnoses - main ICD10	N14.1	Nephropathy induced by other drugs, medicaments and biological substances
41202	Diagnoses - main ICD10	N14.2	Nephropathy induced by unspecified drug, medicament or biological substance
41202	Diagnoses - main ICD10	N14.3	Nephropathy induced by heavy metals
41202	Diagnoses - main ICD10	N14.4	Toxic nephropathy, not elsewhere classified
41202	Diagnoses - main ICD10	N15.8	Other specified renal tubulo-interstitial diseases
41202	Diagnoses - main ICD10	N15.9	Renal tubulo-interstitial disease, unspecified
41202	Diagnoses - main ICD10	N16.1	Renal tubulo-interstitial disorders in neoplastic diseases
41202	Diagnoses - main ICD10	N16.2	Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism
41202	Diagnoses - main ICD10	N16.3	Renal tubulo-interstitial disorders in metabolic diseases
41202	Diagnoses - main ICD10	N16.4	Renal tubulo-interstitial disorders in systemic connective tissue disorders
41202	Diagnoses - main ICD10	N16.5	Renal tubulo-interstitial disorders in transplant rejection
41202	Diagnoses - main ICD10	N16.8	Renal tubulo-interstitial disorders in other diseases classified elsewhere
41204	Diagnoses - secondary ICD10	N12	Tubulo-interstitial nephritis, not specified as acute or chronic
41204	Diagnoses - secondary ICD10	N14.0	Analgesic nephropathy
41204	Diagnoses - secondary ICD10	N14.1	Nephropathy induced by other drugs, medicaments and biological substances
41204	Diagnoses - secondary ICD10	N14.2	Nephropathy induced by unspecified drug, medicament or biological substance
41204	Diagnoses - secondary ICD10	N14.3	Nephropathy induced by heavy metals
41204	Diagnoses - secondary ICD10	N14.4	Toxic nephropathy, not elsewhere classified
41204	Diagnoses - secondary ICD10	N15.8	Other specified renal tubulo-interstitial diseases
41204	Diagnoses - secondary ICD10	N15.9	Renal tubulo-interstitial disease, unspecified
41204	Diagnoses - secondary ICD10	N16.1	Renal tubulo-interstitial disorders in neoplastic diseases
41204	Diagnoses - secondary ICD10	N16.2	Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism
41204	Diagnoses - secondary ICD10	N16.3	Renal tubulo-interstitial disorders in metabolic diseases
41204	Diagnoses - secondary ICD10	N16.4	Renal tubulo-interstitial disorders in systemic connective tissue disorders
41204	Diagnoses - secondary ICD10	N16.5	Renal tubulo-interstitial disorders in transplant rejection
41204	Diagnoses - secondary ICD10	N16.8	Renal tubulo-interstitial disorders in other diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	N12	Tubulo-interstitial nephritis, not specified as acute or chronic
40001	Underlying (primary) cause of death: ICD10	N14.0	Analgesic nephropathy
40001	Underlying (primary) cause of death: ICD10	N14.1	Nephropathy induced by other drugs, medicaments and biological substances
40001	Underlying (primary) cause of death: ICD10	N14.2	Nephropathy induced by unspecified drug, medicament or biological substance
40001	Underlying (primary) cause of death: ICD10	N14.3	Nephropathy induced by heavy metals
40001	Underlying (primary) cause of death: ICD10	N14.4	Toxic nephropathy, not elsewhere classified
40001	Underlying (primary) cause of death: ICD10	N15.8	Other specified renal tubulo-interstitial diseases
40001	Underlying (primary) cause of death: ICD10	N15.9	Renal tubulo-interstitial disease, unspecified
40001	Underlying (primary) cause of death: ICD10	N16.1	Renal tubulo-interstitial disorders in neoplastic diseases
40001	Underlying (primary) cause of death: ICD10	N16.2	Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism
40001	Underlying (primary) cause of death: ICD10	N16.3	Renal tubulo-interstitial disorders in metabolic diseases
40001	Underlying (primary) cause of death: ICD10	N16.4	Renal tubulo-interstitial disorders in systemic connective tissue disorders
40001	Underlying (primary) cause of death: ICD10	N16.5	Renal tubulo-interstitial disorders in transplant rejection
40001	Underlying (primary) cause of death: ICD10	N16.8	Renal tubulo-interstitial disorders in other diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	N12	Tubulo-interstitial nephritis, not specified as acute or chronic
40002	Contributory (secondary) causes of death: ICD10	N14.0	Analgesic nephropathy
40002	Contributory (secondary) causes of death: ICD10	N14.1	Nephropathy induced by other drugs, medicaments and biological substances
40002	Contributory (secondary) causes of death: ICD10	N14.2	Nephropathy induced by unspecified drug, medicament or biological substance
40002	Contributory (secondary) causes of death: ICD10	N14.3	Nephropathy induced by heavy metals
40002	Contributory (secondary) causes of death: ICD10	N14.4	Toxic nephropathy, not elsewhere classified
40002	Contributory (secondary) causes of death: ICD10	N15.8	Other specified renal tubulo-interstitial diseases
40002	Contributory (secondary) causes of death: ICD10	N15.9	Renal tubulo-interstitial disease, unspecified
40002	Contributory (secondary) causes of death: ICD10	N16.1	Renal tubulo-interstitial disorders in neoplastic diseases
40002	Contributory (secondary) causes of death: ICD10	N16.2	Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism
40002	Contributory (secondary) causes of death: ICD10	N16.3	Renal tubulo-interstitial disorders in metabolic diseases
40002	Contributory (secondary) causes of death: ICD10	N16.4	Renal tubulo-interstitial disorders in systemic connective tissue disorders
40002	Contributory (secondary) causes of death: ICD10	N16.5	Renal tubulo-interstitial disorders in transplant rejection
40002	Contributory (secondary) causes of death: ICD10	N16.8	Renal tubulo-interstitial disorders in other diseases classified elsewhere
42040	GP clinical event records	K03T.00	Tubulo-interstit nephritis, not specif as acute or chron
42040	GP clinical event records	K03y200	Other interstitial nephritis
42040	GP clinical event records	K0B1.00	Renal tubulo-interstitial disorder/ neoplastic diseases
42040	GP clinical event records	K0B2.00	Ren tub-interst disordr/blood dis+disordr inv immune mech
42040	GP clinical event records	K0B4000	Renal tubulo-interstitial disorder in SLE
42040	GP clinical event records	K0B4.00	Ren tub-interstitl disordr/systemc connectv tiss disorder
42040	GP clinical event records	K0B5.00	Renal tubulo-interstitial disordrs in transplant rejectn
42040	GP clinical event records	K0B..00	Renal tubulo-interstitial disorders in diseases EC
42040	GP clinical event records	K0C0.00	Analgesic nephropathy
42040	GP clinical event records	K0C1.00	Nephropathy induced by other drugs meds and biologl substncs
42040	GP clinical event records	K0C2.00	Nephropathy induced by unspec drug medicament or biol subs
42040	GP clinical event records	K0C4.00	Toxic nephropathy, not elsewhere classified
42040	GP clinical event records	K0C5.00	Acute drug-induced interstitial nephritis
42040	GP clinical event records	K0C6.00	Chronic lithium nephrotoxicity
42040	GP clinical event records	K0C..00	Drug/heavy-metal-induced tubulo-interstitial and tub conditn
42040	GP clinical event records	Kyu1000	[X]Other chronic tubulo-interstitial nephritis
42040	GP clinical event records	Kyu1400	[X]Nephropathy induced by other drugs+biological substances
42040	GP clinical event records	Kyu1E00	[X]Tubulo-interstit nephritis, not specif as acute or chron
42040	GP clinical event records	Kyu1.00	[X]Renal tubulo-interstitial diseases
42040	GP clinical event records	X30JM	Acute drug-induced interstitial nephritis
42040	GP clinical event records	XaBE1	Renal tubulo-interstitial disorder in systemic lupus erythematosus
42040	GP clinical event records	X30LN	Chronic lithium nephrotoxicity
42040	GP clinical event records	X30JS	Analgesic nephropathy