| Name |
Trigeminal neuralgia (trigem_neur) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
df68df61-c02f-4a74-93bf-e4f6f28938b3 |
| Definition |
A nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face, which may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2655 |
| Female (%) |
1873 (71%) |
| Male (%) |
782 (29%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
61.18 (55.93,66.43) |
| Male |
31.08 (27.0,35.16) |
Incidence stratified by sex
| Female |
5.81 (5.18,6.44) |
| Male |
3.08 (2.58,3.58) |
Incidence stratified by age
| Ages 40-44 |
2.92 (1.86,3.99) |
| Ages 45-49 |
2.9 (1.99,3.81) |
| Ages 50-54 |
3.63 (2.69,4.57) |
| Ages 55-59 |
5.28 (4.25,6.31) |
| Ages 60-64 |
5.14 (4.27,6.01) |
| Ages 65-69 |
5.82 (4.76,6.88) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
43 (37,50) |
69 (63,76) |
89 (83,95) |
| CALIBER |
51 (49,53) |
80 (78,83) |
108 (104,111) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
29(18,44) |
67(54,83) |
89(76,103) |
| Low |
48(34,67) |
67(54,82) |
89(77,103) |
| Medium |
40(27,56) |
68(54,83) |
92(79,106) |
| High |
49(36,65) |
68(55,83) |
81(69,96) |
| Most deprived |
47(35,62) |
76(62,92) |
92(78,108) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
46(39,53) |
70(63,77) |
90(84,97) |
| Scotland |
29(16,47) |
55(41,73) |
54(41,69) |
| Wales |
38(19,66) |
86(64,115) |
126(101,155) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153420, Events=132
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.98 (0.66, 1.47) |
0.928 |
| BMI |
obese |
1.08 (0.69, 1.7) |
0.735 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.16 (0.78, 1.73) |
0.462 |
| smoking |
current |
2.27 (1.45, 3.57) |
0.000355 |
| hypertension |
yes |
1.19 (0.76, 1.85) |
0.449 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1523 |
trigemminal neuralgia |
| 41202 |
Diagnoses - main ICD10 |
G50.0 |
Trigeminal neuralgia |
| 41204 |
Diagnoses - secondary ICD10 |
G50.0 |
Trigeminal neuralgia |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G50.0 |
Trigeminal neuralgia |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G50.0 |
Trigeminal neuralgia |
| 42040 |
GP clinical event records |
1475.00 |
H/O: trigeminal neuralgia |
| 42040 |
GP clinical event records |
A531200 |
Postherpetic trigeminal neuralgia |
| 42040 |
GP clinical event records |
F300.00 |
Post-herpetic trigeminal neuralgia |
| 42040 |
GP clinical event records |
F301000 |
Tic douloureux |
| 42040 |
GP clinical event records |
F301.00 |
Other specified trigeminal neuralgia |
| 42040 |
GP clinical event records |
F301z00 |
Trigeminal neuralgia NOS |