| Name |
Ulcerative colitis (ulc_colitis) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
6be5667e-81e9-44ea-bd6c-1054fcbeb2af |
| Definition |
An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
6523 |
| Female (%) |
3276 (50%) |
| Male (%) |
3247 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
99.96 (93.27,106.65) |
| Male |
111.71 (104.01,119.42) |
Incidence stratified by sex
| Female |
2.81 (2.37,3.24) |
| Male |
3.81 (3.25,4.37) |
Incidence stratified by age
| Ages 40-44 |
2.43 (1.46,3.4) |
| Ages 45-49 |
3.0 (2.07,3.92) |
| Ages 50-54 |
3.14 (2.26,4.01) |
| Ages 55-59 |
3.2 (2.4,4.0) |
| Ages 60-64 |
3.81 (3.06,4.57) |
| Ages 65-69 |
3.31 (2.5,4.11) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
98 (89,108) |
115 (107,124) |
132 (125,140) |
| CALIBER |
70 (68,73) |
89 (86,92) |
115 (112,118) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
102(80,128) |
115(97,135) |
125(110,142) |
| Low |
90(70,116) |
118(99,138) |
119(104,135) |
| Medium |
94(74,119) |
115(97,136) |
123(107,140) |
| High |
96(76,118) |
120(102,140) |
157(139,177) |
| Most deprived |
108(89,130) |
109(92,128) |
141(123,161) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
95(85,106) |
113(104,123) |
130(122,138) |
| Scotland |
115(87,149) |
120(98,145) |
148(126,173) |
| Wales |
107(73,152) |
126(97,160) |
133(107,163) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Genetic correlation
| Genetic correlation (rg) |
P value |
| 0.94 |
2.04e-40 |
Published study: de Lange (2017)
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1463 |
ulcerative colitis |
| 41202 |
Diagnoses - main ICD10 |
K51 |
Ulcerative colitis |
| 41204 |
Diagnoses - secondary ICD10 |
K51 |
Ulcerative colitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K51 |
Ulcerative colitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K51 |
Ulcerative colitis |
| 42040 |
GP clinical event records |
14C4.11 |
H/O: ulcerative colitis |
| 42040 |
GP clinical event records |
J410000 |
Ulcerative ileocolitis |
| 42040 |
GP clinical event records |
J410100 |
Ulcerative colitis |
| 42040 |
GP clinical event records |
J410200 |
Ulcerative rectosigmoiditis |
| 42040 |
GP clinical event records |
J410300 |
Ulcerative proctitis |
| 42040 |
GP clinical event records |
J410400 |
Exacerbation of ulcerative colitis |
| 42040 |
GP clinical event records |
J410.00 |
Ulcerative proctocolitis |
| 42040 |
GP clinical event records |
J410z00 |
Ulcerative proctocolitis NOS |
| 42040 |
GP clinical event records |
J411.00 |
Ulcerative (chronic) enterocolitis |
| 42040 |
GP clinical event records |
J412.00 |
Ulcerative (chronic) ileocolitis |
| 42040 |
GP clinical event records |
J413.00 |
Ulcerative pancolitis |
| 42040 |
GP clinical event records |
J41..00 |
Idiopathic proctocolitis |
| 42040 |
GP clinical event records |
J41..11 |
Mucous colitis and/or proctitis |
| 42040 |
GP clinical event records |
J41..12 |
Ulcerative colitis and/or proctitis |
| 42040 |
GP clinical event records |
J41y.00 |
Other idiopathic proctocolitis |
| 42040 |
GP clinical event records |
J41yz00 |
Other idiopathic proctocolitis NOS |
| 42040 |
GP clinical event records |
J41z.00 |
Idiopathic proctocolitis NOS |
| 42040 |
GP clinical event records |
Jyu4100 |
[X]Other ulcerative colitis |
| 42040 |
GP clinical event records |
N031000 |
Arthropathy in ulcerative colitis |
| 42040 |
GP clinical event records |
N045400 |
Juvenile arthritis in ulcerative colitis |
| 42040 |
GP clinical event records |
XaYzX |
Ulcerative pancolitis |
| 42040 |
GP clinical event records |
XE0ag |
Ulcerative colitis |
| 42040 |
GP clinical event records |
XaK6E |
Exacerbation of ulcerative colitis |
| 42040 |
GP clinical event records |
XE0qC |
H/O: colitis |