Metadata

Name Peptic ulcer disease (ulcer_peptic)
Category Digestive
Sex
Adult Yes
UUID 89b89941-fc76-4fb8-8ef6-4cc3e7cbbf71
Definition Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier.

Ontologies

Disease Ontology (DOID) DOID_750
GWAS Catalogue MONDO_0004247
MeSH D010437
SNOMED-CT 13200003
FinnGen K11_PULC

Key Summary Statistics

Cases from any source

Total 21297
Female (%) 9111 (43%)
Male (%) 12186 (57%)

Year first recorded

ulcer_peptic year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced ulcer_peptic cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of ulcer_peptic

Baseline prevalence stratified by sex

Female 226.44 (216.43,236.45)
Male 442.38 (427.3,457.46)

Incidence stratified by sex

Female 11.56 (10.67,12.46)
Male 16.08 (14.91,17.25)

Incidence stratified by age

Ages 40-44 5.3 (3.86,6.75)
Ages 45-49 9.02 (7.4,10.64)
Ages 50-54 10.37 (8.76,11.98)
Ages 55-59 12.49 (10.88,14.1)
Ages 60-64 16.17 (14.59,17.75)
Ages 65-69 21.42 (19.33,23.52)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB ulcer_peptic prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 173 (160,187) 301 (287,315) 468 (453,482)
CALIBER 155 (152,159) 293 (288,298) 471 (464,478)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 114(90,142) 224(198,252) 373(346,401)
Low 143(116,175) 234(207,262) 415(386,445)
Medium 146(119,176) 276(248,307) 436(406,467)
High 187(159,218) 309(279,341) 470(438,504)
Most deprived 241(212,273) 450(415,488) 684(643,726)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 160(146,174) 288(273,303) 452(436,468)
Scotland 297(250,351) 420(377,466) 643(595,694)
Wales 123(87,170) 227(188,273) 365(321,413)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor Level Hazard Ratio P value
BMI overweight 1.07 (0.82, 1.39) 0.637
BMI obese 2.13 (1.65, 2.77) 1.06e-08
BMI underweight 0 (0, Inf) 0.986
smoking previous 1.48 (1.19, 1.85) 0.000498
smoking current 2.47 (1.87, 3.26) 1.43e-10
hypertension yes 2.21 (1.8, 2.72) 5.76e-14

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1142 gastric/stomach ulcers
20002 Non-cancer illness code, self-reported 1457 duodenal ulcer
20002 Non-cancer illness code, self-reported 1400 peptic ulcer
41202 Diagnoses - main ICD10 K25 Gastric ulcer
41202 Diagnoses - main ICD10 K26 Duodenal ulcer
41202 Diagnoses - main ICD10 K27 Peptic ulcer, site unspecified
41202 Diagnoses - main ICD10 K28 Gastrojejunal ulcer
41204 Diagnoses - secondary ICD10 K25 Gastric ulcer
41204 Diagnoses - secondary ICD10 K26 Duodenal ulcer
41204 Diagnoses - secondary ICD10 K27 Peptic ulcer, site unspecified
41204 Diagnoses - secondary ICD10 K28 Gastrojejunal ulcer
41200 Operative procedures - main OPCS4 G35 Operations on ulcer of stomach
41200 Operative procedures - main OPCS4 G35.1 Closure of perforated ulcer of stomach
41200 Operative procedures - main OPCS4 G35.2 Closure of ulcer of stomach NEC
41200 Operative procedures - main OPCS4 G35.8 Other specified operations on ulcer of stomach
41200 Operative procedures - main OPCS4 G35.9 Unspecified operations on ulcer of stomach
41200 Operative procedures - main OPCS4 G52 Operations on ulcer of duodenum
41200 Operative procedures - main OPCS4 G52.1 Closure of perforated ulcer of duodenum
41200 Operative procedures - main OPCS4 G52.2 Suture of ulcer of duodenum NEC
41200 Operative procedures - main OPCS4 G52.3 Oversew of blood vessel of duodenal ulcer
41200 Operative procedures - main OPCS4 G52.8 Other specified operations on ulcer of duodenum
41200 Operative procedures - main OPCS4 G52.9 Unspecified operations on ulcer of duodenum
41210 Operative procedures - secondary OPCS4 G35 G35
41210 Operative procedures - secondary OPCS4 G35.1 G35.1
41210 Operative procedures - secondary OPCS4 G35.2 G35.2
41210 Operative procedures - secondary OPCS4 G35.8 G35.8
41210 Operative procedures - secondary OPCS4 G35.9 G35.9
41210 Operative procedures - secondary OPCS4 G52 G52
41210 Operative procedures - secondary OPCS4 G52.1 G52.1
41210 Operative procedures - secondary OPCS4 G52.2 G52.2
41210 Operative procedures - secondary OPCS4 G52.3 G52.3
41210 Operative procedures - secondary OPCS4 G52.8 G52.8
41210 Operative procedures - secondary OPCS4 G52.9 G52.9
40001 Underlying (primary) cause of death: ICD10 K25 Gastric ulcer
40001 Underlying (primary) cause of death: ICD10 K26 Duodenal ulcer
40001 Underlying (primary) cause of death: ICD10 K27 Peptic ulcer, site unspecified
40001 Underlying (primary) cause of death: ICD10 K28 Gastrojejunal ulcer
40002 Contributory (secondary) causes of death: ICD10 K25 Gastric ulcer
40002 Contributory (secondary) causes of death: ICD10 K26 Duodenal ulcer
40002 Contributory (secondary) causes of death: ICD10 K27 Peptic ulcer, site unspecified
40002 Contributory (secondary) causes of death: ICD10 K28 Gastrojejunal ulcer
42040 GP clinical event records 14C1.00 H/O: peptic ulcer
42040 GP clinical event records 14C1.11 H/O: duodenal ulcer
42040 GP clinical event records 14C1.12 H/O: gastric ulcer
42040 GP clinical event records 7612111.0 Balfour excision of gastric ulcer
42040 GP clinical event records 7612500.0 Resection of gastric ulcer by cautery
42040 GP clinical event records 761D500 Endoscopic injection haemostasis of duodenal ulcer
42040 GP clinical event records 761D600 Endoscopic injection haemostasis of gastric ulcer
42040 GP clinical event records 761J000 Closure of perforated gastric ulcer
42040 GP clinical event records 761J100 Closure of gastric ulcer NEC
42040 GP clinical event records 761J111 Suture of ulcer of stomach NEC
42040 GP clinical event records 761J.00 Operations on gastric ulcer
42040 GP clinical event records 761J.11 Stomach ulcer operations
42040 GP clinical event records 761Jy00 Other specified operation on gastric ulcer
42040 GP clinical event records 761Jz00 Operation on gastric ulcer NOS
42040 GP clinical event records 7627000.0 Closure of perforated duodenal ulcer
42040 GP clinical event records 7627100.0 Suture of duodenal ulcer not elsewhere classified
42040 GP clinical event records 7627200.0 Oversew of blood vessel of duodenal ulcer
42040 GP clinical event records 7627.00 Operations on duodenal ulcer
42040 GP clinical event records 7627y00 Other specified operation on duodenal ulcer
42040 GP clinical event records 7627z00 Operation on duodenal ulcer NOS
42040 GP clinical event records J110000 Acute gastric ulcer without mention of complication
42040 GP clinical event records J110100 Acute gastric ulcer with haemorrhage
42040 GP clinical event records J110111 Bleeding acute gastric ulcer
42040 GP clinical event records J110200 Acute gastric ulcer with perforation
42040 GP clinical event records J110300 Acute gastric ulcer with haemorrhage and perforation
42040 GP clinical event records J110400 Acute gastric ulcer with obstruction
42040 GP clinical event records J110.00 Acute gastric ulcer
42040 GP clinical event records J110y00 Acute gastric ulcer unspecified
42040 GP clinical event records J110z00 Acute gastric ulcer NOS
42040 GP clinical event records J111000 Chronic gastric ulcer without mention of complication
42040 GP clinical event records J111100 Chronic gastric ulcer with haemorrhage
42040 GP clinical event records J111111 Bleeding chronic gastric ulcer
42040 GP clinical event records J111200 Chronic gastric ulcer with perforation
42040 GP clinical event records J111211 Perforated chronic gastric ulcer
42040 GP clinical event records J111300 Chronic gastric ulcer with haemorrhage and perforation
42040 GP clinical event records J111400 Chronic gastric ulcer with obstruction
42040 GP clinical event records J111.00 Chronic gastric ulcer
42040 GP clinical event records J111y00 Chronic gastric ulcer unspecified
42040 GP clinical event records J111z00 Chronic gastric ulcer NOS
42040 GP clinical event records J112.00 Anti-platelet induced gastric ulcer
42040 GP clinical event records J112z00 Anti-platelet induced gastric ulcer NOS
42040 GP clinical event records J113.00 Non steroidal anti inflammatory drug induced gastric ulcer
42040 GP clinical event records J113z00 Non steroidal anti inflammatory drug induced gastric ulc NOS
42040 GP clinical event records J11..00 Gastric ulcer - (GU)
42040 GP clinical event records J11..11 Prepyloric ulcer
42040 GP clinical event records J11..12 Pyloric ulcer
42040 GP clinical event records J11y000 Unspecified gastric ulcer without mention of complication
42040 GP clinical event records J11y100 Unspecified gastric ulcer with haemorrhage
42040 GP clinical event records J11y200 Unspecified gastric ulcer with perforation
42040 GP clinical event records J11y400 Unspecified gastric ulcer with obstruction
42040 GP clinical event records J11y.00 Unspecified gastric ulcer
42040 GP clinical event records J11yy00 Unspec gastric ulcer; unspec haemorrhage and/or perforation
42040 GP clinical event records J11yz00 Unspecified gastric ulcer NOS
42040 GP clinical event records J11z.00 Gastric ulcer NOS
42040 GP clinical event records J11z.11 Gastric erosions
42040 GP clinical event records J11z.12 Multiple gastric ulcers
42040 GP clinical event records J120000 Acute duodenal ulcer without mention of complication
42040 GP clinical event records J120100 Acute duodenal ulcer with haemorrhage
42040 GP clinical event records J120200 Acute duodenal ulcer with perforation
42040 GP clinical event records J120300 Acute duodenal ulcer with haemorrhage and perforation
42040 GP clinical event records J120400 Acute duodenal ulcer with obstruction
42040 GP clinical event records J120.00 Acute duodenal ulcer
42040 GP clinical event records J120y00 Acute duodenal ulcer unspecified
42040 GP clinical event records J120z00 Acute duodenal ulcer NOS
42040 GP clinical event records J121000 Chronic duodenal ulcer without mention of complication
42040 GP clinical event records J121100 Chronic duodenal ulcer with haemorrhage
42040 GP clinical event records J121111 Bleeding chronic duodenal ulcer
42040 GP clinical event records J121200 Chronic duodenal ulcer with perforation
42040 GP clinical event records J121211 Perforated chronic duodenal ulcer
42040 GP clinical event records J121300 Chronic duodenal ulcer with haemorrhage and perforation
42040 GP clinical event records J121400 Chronic duodenal ulcer with obstruction
42040 GP clinical event records J121.00 Chronic duodenal ulcer
42040 GP clinical event records J121y00 Chronic duodenal ulcer unspecified
42040 GP clinical event records J121z00 Chronic duodenal ulcer NOS
42040 GP clinical event records J122.00 Duodenal ulcer disease
42040 GP clinical event records J123.00 Duodenal erosion
42040 GP clinical event records J124.00 Recurrent duodenal ulcer
42040 GP clinical event records J125.00 Anti-platelet induced duodenal ulcer
42040 GP clinical event records J126.00 Non steroidal anti inflammatory drug induced duodenal ulcer
42040 GP clinical event records J12..00 Duodenal ulcer - (DU)
42040 GP clinical event records J12y000 Unspecified duodenal ulcer without mention of complication
42040 GP clinical event records J12y100 Unspecified duodenal ulcer with haemorrhage
42040 GP clinical event records J12y200 Unspecified duodenal ulcer with perforation
42040 GP clinical event records J12y300 Unspecified duodenal ulcer with haemorrhage and perforation
42040 GP clinical event records J12y400 Unspecified duodenal ulcer with obstruction
42040 GP clinical event records J12y.00 Unspecified duodenal ulcer
42040 GP clinical event records J12yy00 Unspec duodenal ulcer; unspec haemorrhage and/or perforation
42040 GP clinical event records J12yz00 Unspecified duodenal ulcer NOS
42040 GP clinical event records J12z.00 Duodenal ulcer NOS
42040 GP clinical event records J130000 Acute peptic ulcer without mention of complication
42040 GP clinical event records J130100 Acute peptic ulcer with haemorrhage
42040 GP clinical event records J130200 Acute peptic ulcer with perforation
42040 GP clinical event records J130300 Acute peptic ulcer with haemorrhage and perforation
42040 GP clinical event records J130.00 Acute peptic ulcer
42040 GP clinical event records J130y00 Acute peptic ulcer unspecified
42040 GP clinical event records J130z00 Acute peptic ulcer NOS
42040 GP clinical event records J131000 Chronic peptic ulcer without mention of complication
42040 GP clinical event records J131100 Chronic peptic ulcer with haemorrhage
42040 GP clinical event records J131200 Chronic peptic ulcer with perforation
42040 GP clinical event records J131400 Chronic peptic ulcer with obstruction
42040 GP clinical event records J131.00 Chronic peptic ulcer
42040 GP clinical event records J131y00 Chronic peptic ulcer unspecified
42040 GP clinical event records J131z00 Chronic peptic ulcer NOS
42040 GP clinical event records J13..00 Peptic ulcer - (PU) site unspecified
42040 GP clinical event records J13..11 Stress ulcer NOS
42040 GP clinical event records J13y000 Unspecified peptic ulcer without mention of complication
42040 GP clinical event records J13y100 Unspecified peptic ulcer with haemorrhage
42040 GP clinical event records J13y200 Unspecified peptic ulcer with perforation
42040 GP clinical event records J13y300 Unspecified peptic ulcer with haemorrhage and perforation
42040 GP clinical event records J13y400 Unspecified peptic ulcer with obstruction
42040 GP clinical event records J13y.00 Unspecified peptic ulcer
42040 GP clinical event records J13yz00 Unspecified peptic ulcer NOS
42040 GP clinical event records J13z.00 Peptic ulcer NOS
42040 GP clinical event records J140100 Acute gastrojejunal ulcer with haemorrhage
42040 GP clinical event records J140200 Acute gastrojejunal ulcer with perforation
42040 GP clinical event records J140300 Acute gastrojejunal ulcer with haemorrhage and perforation
42040 GP clinical event records J140.00 Acute gastrojejunal ulcer
42040 GP clinical event records J140z00 Acute gastrojejunal ulcer NOS
42040 GP clinical event records J141300 Chronic gastrojejunal ulcer with haemorrhage and perforation
42040 GP clinical event records J141.00 Chronic gastrojejunal ulcer
42040 GP clinical event records J14..00 Gastrojejunal ulcer (GJU)
42040 GP clinical event records J14..11 Anastomotic ulcer
42040 GP clinical event records J14..12 Gastrocolic ulcer
42040 GP clinical event records J14..13 Jejunal ulcer
42040 GP clinical event records J14y100 Unspecified gastrojejunal ulcer with haemorrhage
42040 GP clinical event records J14y200 Unspecified gastrojejunal ulcer with perforation
42040 GP clinical event records J14y.00 Unspecified gastrojejunal ulcer
42040 GP clinical event records J14yz00 Unspecified gastrojejunal ulcer NOS
42040 GP clinical event records J14z.00 Gastrojejunal ulcer NOS
42040 GP clinical event records J17y800 Healed gastric ulcer leaving a scar
42040 GP clinical event records ZV12711 [V]Personal history of peptic ulcer
42040 GP clinical event records ZV12712 [V]Personal history of duodenal ulcer
42040 GP clinical event records ZV12C00 [V] Personal history of gastric ulcer
42040 GP clinical event records XaFBs Endoscopic injection haemostasis of gastric ulcer
42040 GP clinical event records XE24Y [V]Personal history of digestive system disease
42040 GP clinical event records XaLWs Anti-platelet induced duodenal ulcer
42040 GP clinical event records XaMO5 Non steroidal anti inflammatory drug induced gastric ulcer
42040 GP clinical event records XE0aR Peptic ulcer - (PU) site unspecified
42040 GP clinical event records X302G Duodenal erosion
42040 GP clinical event records XaCLu [V] Personal history of gastric ulcer
42040 GP clinical event records XE0Cf Open excision of lesion of stomach NEC
42040 GP clinical event records XaMO6 Non steroidal anti inflammatory drug induced gastric ulcer NOS
42040 GP clinical event records XE0aQ Gastric ulcer NOS
42040 GP clinical event records XE0qB H/O: peptic ulcer
42040 GP clinical event records X302b Duodenal ulcer disease
42040 GP clinical event records XaFBq Endoscopic injection haemostasis of duodenal ulcer
42040 GP clinical event records XaLWr Anti-platelet induced gastric ulcer NOS
42040 GP clinical event records XaLdV Oversew of blood vessel of duodenal ulcer
42040 GP clinical event records XaMO7 Non steroidal anti inflammatory drug induced duodenal ulcer
42040 GP clinical event records XaLWq Anti-platelet induced gastric ulcer
42040 GP clinical event records XE0Cr Closure of gastric ulcer NEC