| Name |
Unstable Angina (unstable_angina) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
965ddea4-871c-4552-803f-994856232829 |
| Definition |
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
8927 |
| Female (%) |
2985 (33%) |
| Male (%) |
5942 (67%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
54.81 (49.84,59.78) |
| Male |
152.45 (143.47,161.44) |
Incidence stratified by sex
| Female |
5.55 (4.94,6.17) |
| Male |
13.93 (12.86,15.0) |
Incidence stratified by age
| Ages 40-44 |
2.21 (1.29,3.14) |
| Ages 45-49 |
4.17 (3.08,5.26) |
| Ages 50-54 |
6.5 (5.24,7.76) |
| Ages 55-59 |
9.09 (7.73,10.44) |
| Ages 60-64 |
11.36 (10.05,12.66) |
| Ages 65-69 |
16.44 (14.63,18.24) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
42 (36,49) |
118 (109,127) |
245 (235,256) |
| CALIBER |
56 (54,58) |
161 (158,165) |
311 (305,316) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
37(24,54) |
65(51,81) |
180(161,200) |
| Low |
34(21,51) |
85(69,104) |
206(186,228) |
| Medium |
14(6,25) |
120(101,141) |
220(199,242) |
| High |
33(22,48) |
111(94,131) |
267(242,293) |
| Most deprived |
78(62,97) |
203(179,229) |
380(350,413) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
43(36,51) |
120(111,130) |
249(238,261) |
| Scotland |
36(21,57) |
106(85,131) |
223(195,254) |
| Wales |
38(19,68) |
111(84,144) |
234(199,274) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153979, Events=141
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.41 (0.92, 2.17) |
0.113 |
| BMI |
obese |
1.52 (0.95, 2.43) |
0.0832 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.89 (0.63, 1.27) |
0.531 |
| smoking |
current |
0.83 (0.44, 1.56) |
0.561 |
| hypertension |
yes |
1.5 (1.06, 2.12) |
0.0207 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I20.0 |
Unstable angina |
| 41204 |
Diagnoses - secondary ICD10 |
I20.0 |
Unstable angina |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I20.0 |
Unstable angina |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I20.0 |
Unstable angina |
| 42040 |
GP clinical event records |
662K300 |
Angina control - worsening |
| 42040 |
GP clinical event records |
G311300 |
Refractory angina |
| 42040 |
GP clinical event records |
G311400 |
Worsening angina |
| 42040 |
GP clinical event records |
G311.00 |
Preinfarction syndrome |
| 42040 |
GP clinical event records |
G311.11 |
Crescendo angina |
| 42040 |
GP clinical event records |
G311.12 |
Impending infarction |
| 42040 |
GP clinical event records |
G311.13 |
Unstable angina |
| 42040 |
GP clinical event records |
G311.14 |
Angina at rest |
| 42040 |
GP clinical event records |
G311100 |
Unstable angina |
| 42040 |
GP clinical event records |
G311200 |
Angina at rest |
| 42040 |
GP clinical event records |
G311z00 |
Preinfarction syndrome NOS |
| 42040 |
GP clinical event records |
G312.00 |
Coronary thrombosis not resulting in myocardial infarction |
| 42040 |
GP clinical event records |
G31y000 |
Acute coronary insufficiency |
| 42040 |
GP clinical event records |
G33z000 |
Status anginosus |
| 42040 |
GP clinical event records |
G311500 |
Acute coronary syndrome |
| 42040 |
GP clinical event records |
X2007 |
Angina at rest |
| 42040 |
GP clinical event records |
X2009 |
Unstable angina |
| 42040 |
GP clinical event records |
XaINF |
Acute coronary syndrome |
| 42040 |
GP clinical event records |
XE0Ui |
Worsening angina |
| 42040 |
GP clinical event records |
XaFsG |
Refractory angina |