Urinary Incontinence

Metadata

Name	Urinary Incontinence (urine_incont)
Category	Genitourinary
Sex
Adult	Yes
UUID	bff1f523-dc25-4287-bbf0-0276589fea26
Definition	Involuntary loss of urine, such as leaking of urine.

Ontologies

GWAS Catalogue	HP_0000020
MeSH	D014549
SNOMED-CT	165232002
FinnGen	R18_UNSPE_URINARY_INCONTINENCE

Key Summary Statistics

Cases from any source

Total	21841
Female (%)	18605 (85%)
Male (%)	3236 (15%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	600.82 (584.83,616.81)
Male	80.78 (74.21,87.34)

Incidence stratified by sex

Female	49.2 (47.3,51.09)
Male	12.75 (11.73,13.77)

Incidence stratified by age

Ages 40-44	25.79 (22.6,28.99)
Ages 45-49	27.49 (24.64,30.34)
Ages 50-54	27.84 (25.17,30.5)
Ages 55-59	32.88 (30.25,35.5)
Ages 60-64	33.24 (30.97,35.52)
Ages 65-69	39.17 (36.34,42.0)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	354 (337,372)	469 (454,485)	583 (568,599)
CALIBER	388 (382,393)	536 (529,543)	673 (665,681)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	311(273,352)	411(379,445)	539(508,572)
Low	331(292,373)	424(392,459)	541(509,573)
Medium	310(273,349)	481(447,518)	552(520,585)
High	351(315,390)	468(434,503)	599(565,636)
Most deprived	437(398,478)	561(523,601)	707(667,748)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	360(341,380)	475(457,493)	582(565,600)
Scotland	292(249,340)	377(340,418)	497(457,539)
Wales	399(333,474)	570(510,635)	729(668,794)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1202	urinary frequency / incontinence
41202	Diagnoses - main ICD10	N39.3	Stress incontinence
41202	Diagnoses - main ICD10	N39.4	Other specified urinary incontinence
41204	Diagnoses - secondary ICD10	N39.3	Stress incontinence
41204	Diagnoses - secondary ICD10	N39.4	Other specified urinary incontinence
40001	Underlying (primary) cause of death: ICD10	N39.3	Stress incontinence
40001	Underlying (primary) cause of death: ICD10	N39.4	Other specified urinary incontinence
40002	Contributory (secondary) causes of death: ICD10	N39.3	Stress incontinence
40002	Contributory (secondary) causes of death: ICD10	N39.4	Other specified urinary incontinence
42040	GP clinical event records	1593.00	H/O: stress incontinence
42040	GP clinical event records	16F..00	Double incontinence
42040	GP clinical event records	1A23.00	Incontinence of urine
42040	GP clinical event records	1A24.00	Stress incontinence
42040	GP clinical event records	1A24.11	Stress incontinence - symptom
42040	GP clinical event records	1A26.00	Urge incontinence of urine
42040	GP clinical event records	3940.00	Bladder: incontinent
42040	GP clinical event records	7B33800	Insertion retropubic device stress urinary incontinence NEC
42040	GP clinical event records	7B33C00	Insertion retropubic dev fem stress urinary incontinence NEC
42040	GP clinical event records	7B42111	Insertion of Kaufman prosthesis for male incontinence
42040	GP clinical event records	7B42113	Insertion of Rosen prosthesis for male incontinence
42040	GP clinical event records	8C14.00	Incontinence care
42040	GP clinical event records	8D71.00	Incontinence control
42040	GP clinical event records	8D7..12	Incontinence control
42040	GP clinical event records	8HTX.00	Referral to incontinence clinic
42040	GP clinical event records	K198.00	Stress incontinence
42040	GP clinical event records	K586.00	Stress incontinence - female
42040	GP clinical event records	Kyu5A00	[X]Other specified urinary incontinence
42040	GP clinical event records	R083100	[D]Urethral sphincter incontinence
42040	GP clinical event records	R083200	[D] Urge incontinence
42040	GP clinical event records	R083.00	[D]Incontinence of urine
42040	GP clinical event records	R083z00	[D]Incontinence of urine NOS
42040	GP clinical event records	Z9EA.00	Provision of incontinence appliance
42040	GP clinical event records	XE0iC	Urinary bladder control
42040	GP clinical event records	XaJtx	Referral to incontinence clinic
42040	GP clinical event records	X30C5	Double incontinence
42040	GP clinical event records	XaMtf	Insertion of retropubic device for female stress urinary incontinence NEC
42040	GP clinical event records	XE0kn	Incontinence control
42040	GP clinical event records	XaMAm	Insertion of retropubic device for stress urinary incontinence NEC