Metadata

Name Urolithiasis (urolithiasis)
Category Genitourinary
Sex
Adult Yes
UUID b114ada9-1a1c-479e-b5ff-fbfa27df2a3b
Definition A urinary system disease that is characterized by the formation of stony concretions in the bladder or urinary tract.

Ontologies

Disease Ontology (DOID) 0080653
GWAS Catalogue MONDO_0024647
MeSH D052878
SNOMED-CT 95566004
FinnGen N14_UROLITHIASIS

Key Summary Statistics

Cases from any source

Total 15901
Female (%) 5123 (32%)
Male (%) 10778 (68%)

Year first recorded

urolithiasis year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced urolithiasis cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of urolithiasis

Baseline prevalence stratified by sex

Female 133.44 (125.72,141.16)
Male 373.36 (359.46,387.27)

Incidence stratified by sex

Female 8.53 (7.77,9.3)
Male 18.67 (17.41,19.92)

Incidence stratified by age

Ages 40-44 11.05 (8.97,13.14)
Ages 45-49 11.19 (9.39,13.0)
Ages 50-54 11.69 (9.98,13.39)
Ages 55-59 13.79 (12.11,15.48)
Ages 60-64 13.29 (11.86,14.71)
Ages 65-69 15.52 (13.76,17.28)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB urolithiasis prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 211 (197,226) 302 (289,316) 361 (349,374)
CALIBER 270 (266,274) 349 (344,355) 437 (431,444)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 185(154,220) 282(253,313) 326(301,353)
Low 210(177,248) 299(268,332) 364(337,392)
Medium 196(164,231) 306(276,338) 370(343,400)
High 203(174,236) 281(252,312) 367(339,398)
Most deprived 249(219,282) 344(313,377) 383(353,416)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 209(193,225) 299(284,315) 359(345,373)
Scotland 228(187,275) 343(305,385) 404(366,445)
Wales 213(163,273) 265(222,315) 322(280,367)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor Level Hazard Ratio P value
BMI overweight 1.47 (1.07, 2.01) 0.0165
BMI obese 2.46 (1.81, 3.35) 1.19e-08
BMI underweight 0 (0, Inf) 0.998
smoking previous 1.06 (0.81, 1.39) 0.676
smoking current 0.75 (0.46, 1.22) 0.25
hypertension yes 0.83 (0.58, 1.19) 0.31

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1197 kidney stone/ureter stone/bladder stone
41202 Diagnoses - main ICD10 N13.2 Hydronephrosis with renal and ureteral calculous obstruction
41202 Diagnoses - main ICD10 N20.0 Calculus of kidney
41202 Diagnoses - main ICD10 N20.1 Calculus of ureter
41202 Diagnoses - main ICD10 N20.2 Calculus of kidney with calculus of ureter
41202 Diagnoses - main ICD10 N20.9 Urinary calculus, unspecified
41202 Diagnoses - main ICD10 N21.0 Calculus in bladder
41202 Diagnoses - main ICD10 N21.1 Calculus in urethra
41202 Diagnoses - main ICD10 N21.8 Other lower urinary tract calculus
41202 Diagnoses - main ICD10 N21.9 Calculus of lower urinary tract, unspecified
41202 Diagnoses - main ICD10 N22.8 Calculus of urinary tract in other diseases classified elsewhere
41202 Diagnoses - main ICD10 N23.X Unspecified renal colic
41204 Diagnoses - secondary ICD10 N13.2 Hydronephrosis with renal and ureteral calculous obstruction
41204 Diagnoses - secondary ICD10 N20.0 Calculus of kidney
41204 Diagnoses - secondary ICD10 N20.1 Calculus of ureter
41204 Diagnoses - secondary ICD10 N20.2 Calculus of kidney with calculus of ureter
41204 Diagnoses - secondary ICD10 N20.9 Urinary calculus, unspecified
41204 Diagnoses - secondary ICD10 N21.0 Calculus in bladder
41204 Diagnoses - secondary ICD10 N21.1 Calculus in urethra
41204 Diagnoses - secondary ICD10 N21.8 Other lower urinary tract calculus
41204 Diagnoses - secondary ICD10 N21.9 Calculus of lower urinary tract, unspecified
41204 Diagnoses - secondary ICD10 N22.8 Calculus of urinary tract in other diseases classified elsewhere
41204 Diagnoses - secondary ICD10 N23.X Unspecified renal colic
41200 Operative procedures - main OPCS4 M06.1 Open removal of calculus from kidney
41200 Operative procedures - main OPCS4 M09 Therapeutic endoscopic operations on calculus of kidney
41200 Operative procedures - main OPCS4 M09.1 Endoscopic ultrasound fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M09.2 Endoscopic electrohydraulic shockwave fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M09.3 Endoscopic laser fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M09.4 Endoscopic extraction of calculus of kidney NEC
41200 Operative procedures - main OPCS4 M09.8 Other specified therapeutic endoscopic operations on calculus of kidney
41200 Operative procedures - main OPCS4 M09.9 Unspecified therapeutic endoscopic operations on calculus of kidney
41200 Operative procedures - main OPCS4 M14 Extracorporeal fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M14.1 Extracorporeal shock wave lithotripsy of calculus of kidney
41200 Operative procedures - main OPCS4 M14.8 Other specified extracorporeal fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M14.9 Unspecified extracorporeal fragmentation of calculus of kidney
41200 Operative procedures - main OPCS4 M16.4 Percutaneous nephrolithotomy NEC
41200 Operative procedures - main OPCS4 M23.1 Open ureterolithotomy
41200 Operative procedures - main OPCS4 M26.1 Nephroscopic laser fragmentation of calculus of ureter
41200 Operative procedures - main OPCS4 M26.2 Nephroscopic fragmentation of calculus of ureter NEC
41200 Operative procedures - main OPCS4 M26.3 Nephroscopic extraction of calculus of ureter
41200 Operative procedures - main OPCS4 M27.1 Ureteroscopic laser fragmentation of calculus of ureter
41200 Operative procedures - main OPCS4 M27.2 Ureteroscopic fragmentation of calculus of ureter NEC
41200 Operative procedures - main OPCS4 M27.3 Ureteroscopic extraction of calculus of ureter
41200 Operative procedures - main OPCS4 M28 Other endoscopic removal of calculus from ureter
41200 Operative procedures - main OPCS4 M28.1 Endoscopic laser fragmentation of calculus of ureter NEC
41200 Operative procedures - main OPCS4 M28.2 Endoscopic fragmentation of calculus of ureter NEC
41200 Operative procedures - main OPCS4 M28.3 Endoscopic extraction of calculus of ureter NEC
41200 Operative procedures - main OPCS4 M28.4 Endoscopic catheter drainage of calculus of ureter
41200 Operative procedures - main OPCS4 M28.5 Endoscopic drainage of calculus of ureter by dilation of ureter
41200 Operative procedures - main OPCS4 M28.8 Other specified other endoscopic removal of calculus from ureter
41200 Operative procedures - main OPCS4 M28.9 Unspecified other endoscopic removal of calculus from ureter
41200 Operative procedures - main OPCS4 M31 Extracorporeal fragmentation of calculus of ureter
41200 Operative procedures - main OPCS4 M31.1 Extracorporeal shockwave lithotripsy of calculus of ureter
41200 Operative procedures - main OPCS4 M31.8 Other specified extracorporeal fragmentation of calculus of ureter
41200 Operative procedures - main OPCS4 M31.9 Unspecified extracorporeal fragmentation of calculus of ureter
41200 Operative procedures - main OPCS4 M39.1 Open removal of calculus from bladder
41200 Operative procedures - main OPCS4 M44.2 Endoscopic extraction of calculus of bladder NEC
41200 Operative procedures - main OPCS4 M75.4 Open extraction of calculus from urethra
41200 Operative procedures - main OPCS4 M86.1 Endoscopic extraction of calculus of urinary diversion
41210 Operative procedures - secondary OPCS4 M06.1 M06.1
41210 Operative procedures - secondary OPCS4 M09 M09
41210 Operative procedures - secondary OPCS4 M09.1 M09.1
41210 Operative procedures - secondary OPCS4 M09.2 M09.2
41210 Operative procedures - secondary OPCS4 M09.3 M09.3
41210 Operative procedures - secondary OPCS4 M09.4 M09.4
41210 Operative procedures - secondary OPCS4 M09.8 M09.8
41210 Operative procedures - secondary OPCS4 M09.9 M09.9
41210 Operative procedures - secondary OPCS4 M14 M14
41210 Operative procedures - secondary OPCS4 M14.1 M14.1
41210 Operative procedures - secondary OPCS4 M14.8 M14.8
41210 Operative procedures - secondary OPCS4 M14.9 M14.9
41210 Operative procedures - secondary OPCS4 M16.4 M16.4
41210 Operative procedures - secondary OPCS4 M23.1 M23.1
41210 Operative procedures - secondary OPCS4 M26.1 M26.1
41210 Operative procedures - secondary OPCS4 M26.2 M26.2
41210 Operative procedures - secondary OPCS4 M26.3 M26.3
41210 Operative procedures - secondary OPCS4 M27.1 M27.1
41210 Operative procedures - secondary OPCS4 M27.2 M27.2
41210 Operative procedures - secondary OPCS4 M27.3 M27.3
41210 Operative procedures - secondary OPCS4 M28 M28
41210 Operative procedures - secondary OPCS4 M28.1 M28.1
41210 Operative procedures - secondary OPCS4 M28.2 M28.2
41210 Operative procedures - secondary OPCS4 M28.3 M28.3
41210 Operative procedures - secondary OPCS4 M28.4 M28.4
41210 Operative procedures - secondary OPCS4 M28.5 M28.5
41210 Operative procedures - secondary OPCS4 M28.8 M28.8
41210 Operative procedures - secondary OPCS4 M28.9 M28.9
41210 Operative procedures - secondary OPCS4 M31 M31
41210 Operative procedures - secondary OPCS4 M31.1 M31.1
41210 Operative procedures - secondary OPCS4 M31.8 M31.8
41210 Operative procedures - secondary OPCS4 M31.9 M31.9
41210 Operative procedures - secondary OPCS4 M39.1 M39.1
41210 Operative procedures - secondary OPCS4 M44.2 M44.2
41210 Operative procedures - secondary OPCS4 M75.4 M75.4
41210 Operative procedures - secondary OPCS4 M86.1 M86.1
40001 Underlying (primary) cause of death: ICD10 N13.2 Hydronephrosis with renal and ureteral calculous obstruction
40001 Underlying (primary) cause of death: ICD10 N20.0 Calculus of kidney
40001 Underlying (primary) cause of death: ICD10 N20.1 Calculus of ureter
40001 Underlying (primary) cause of death: ICD10 N20.2 Calculus of kidney with calculus of ureter
40001 Underlying (primary) cause of death: ICD10 N20.9 Urinary calculus, unspecified
40001 Underlying (primary) cause of death: ICD10 N21.0 Calculus in bladder
40001 Underlying (primary) cause of death: ICD10 N21.1 Calculus in urethra
40001 Underlying (primary) cause of death: ICD10 N21.8 Other lower urinary tract calculus
40001 Underlying (primary) cause of death: ICD10 N21.9 Calculus of lower urinary tract, unspecified
40001 Underlying (primary) cause of death: ICD10 N22.8 Calculus of urinary tract in other diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 N23.X Unspecified renal colic
40002 Contributory (secondary) causes of death: ICD10 N13.2 Hydronephrosis with renal and ureteral calculous obstruction
40002 Contributory (secondary) causes of death: ICD10 N20.0 Calculus of kidney
40002 Contributory (secondary) causes of death: ICD10 N20.1 Calculus of ureter
40002 Contributory (secondary) causes of death: ICD10 N20.2 Calculus of kidney with calculus of ureter
40002 Contributory (secondary) causes of death: ICD10 N20.9 Urinary calculus, unspecified
40002 Contributory (secondary) causes of death: ICD10 N21.0 Calculus in bladder
40002 Contributory (secondary) causes of death: ICD10 N21.1 Calculus in urethra
40002 Contributory (secondary) causes of death: ICD10 N21.8 Other lower urinary tract calculus
40002 Contributory (secondary) causes of death: ICD10 N21.9 Calculus of lower urinary tract, unspecified
40002 Contributory (secondary) causes of death: ICD10 N22.8 Calculus of urinary tract in other diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 N23.X Unspecified renal colic
42040 GP clinical event records 14D3.00 H/O: urinary stone
42040 GP clinical event records 1A52.00 Renal colic
42040 GP clinical event records 1A52.11 Renal colic, symptom
42040 GP clinical event records 4G41.00 O/E: oxalate renal calculus
42040 GP clinical event records 4G42.00 O/E: phosphate -staghorn-stone
42040 GP clinical event records 4G42.11 Phosphate kidney stone
42040 GP clinical event records 4G43.00 O/E: uric acid renal calculus
42040 GP clinical event records 4G44.00 O/E: cystine renal calculus
42040 GP clinical event records 4G4..00 O/E: renal calculus
42040 GP clinical event records 4G4..11 O/E: kidney stone
42040 GP clinical event records 4G4Z.00 O/E: renal stone NOS
42040 GP clinical event records 4G6..00 O/E - ureteric calculus
42040 GP clinical event records 4G7..00 O/E - urethral calculus
42040 GP clinical event records 4G81.00 O/E - vesical oxalate calculus
42040 GP clinical event records 4G81.11 Oxalate bladder stone
42040 GP clinical event records 4G82.00 O/E-vesical uric acid calculus
42040 GP clinical event records 4G82.11 Uric acid bladder stone
42040 GP clinical event records 4G83.00 O/E-vesical phosphate calculus
42040 GP clinical event records 4G83.11 Phosphate bladder stone
42040 GP clinical event records 4G8..00 O/E - bladder calculus
42040 GP clinical event records 4G8Z.00 O/E - bladder calculus NOS
42040 GP clinical event records 7B05000 Unspecified open removal of calculus from kidney
42040 GP clinical event records 7B07000 Nephroscopy and ultrasound lithotripsy of renal calculus
42040 GP clinical event records 7B07011 Endoscopic ultrasound fragmentation of renal calculus
42040 GP clinical event records 7B07100 Nephroscopy & electrohydraulic lithotripsy of renal calculus
42040 GP clinical event records 7B07200 Nephroscopy and laser lithotripsy of renal calculus
42040 GP clinical event records 7B07211 Endoscopic laser fragmentation of renal calculus
42040 GP clinical event records 7B07400 Endoscopic extraction of calculus of kidney nec
42040 GP clinical event records 7B07.00 Percutaneous renal stone surgery
42040 GP clinical event records 7B07.11 Nephroscopic percutaneous lithotripsy of renal calculus
42040 GP clinical event records 7B07.12 Percutaneous lithotripsy of renal calculus
42040 GP clinical event records 7B07y00 Other specified percutaneous renal stone surgery
42040 GP clinical event records 7B07z00 Percutaneous renal stone surgery NOS
42040 GP clinical event records 7B0B000 ESWL for renal calculus of unspecified size
42040 GP clinical event records 7B0B100 ESWL for renal calculus less than 2 cm in diameter
42040 GP clinical event records 7B0B200 ESWL for renal calculus 2 cm or more in diameter
42040 GP clinical event records 7B0B.00 Extracorporeal shockwave lithotripsy for renal calculus
42040 GP clinical event records 7B0B.11 Extracorporeal fragmentation of renal calculus
42040 GP clinical event records 7B0By00 Extracorporeal shockwave lithotripsy for renal calculus OS
42040 GP clinical event records 7B0Bz00 Extracorporeal shockwave lithotripsy for renal calculus NOS
42040 GP clinical event records 7B17000 Nephroscopic laser lithotripsy of ureteric calculus
42040 GP clinical event records 7B17011 Nephroscopic laser fragmentation of ureteric calculus
42040 GP clinical event records 7B17100 Other nephroscopic fragmentation of ureteric calculus
42040 GP clinical event records 7B17111 Other nephroscopic lithotripsy of ureteric calculus
42040 GP clinical event records 7B17200 Nephroscopic extraction of ureteric calculus
42040 GP clinical event records 7B18000 Ureteroscopic laser lithotripsy of ureteric calculus
42040 GP clinical event records 7B18011 Ureteroscopic laser fragmentation of ureteric calculus
42040 GP clinical event records 7B18100 Other ureteroscopic fragmentation of ureteric calculus
42040 GP clinical event records 7B18200 Ureteroscopic extraction of ureteric calculus
42040 GP clinical event records 7B18.00 Ureteroscopic operations for ureteric calculus
42040 GP clinical event records 7B19000 Cystoscopic laser lithotripsy of ureteric calculus
42040 GP clinical event records 7B19100 Other cystoscopic fragmentation of ureteric calculus
42040 GP clinical event records 7B19200 Cystoscopic extraction of ureteric calculus
42040 GP clinical event records 7B19211 Basket extraction of ureteric calculus
42040 GP clinical event records 7B19212 Dormia basket extraction of ureteric calculus
42040 GP clinical event records 7B19300 Cystoscopic catheter drainage for ureteric calculus
42040 GP clinical event records 7B19400 Cystoscopic dilation of ureter for drainage of calculus
42040 GP clinical event records 7B19.00 Cystoscopic removal of ureteric calculus
42040 GP clinical event records 7B19y00 Other specified cystoscopic removal of ureteric calculus
42040 GP clinical event records 7B19z00 Cystoscopic removal of ureteric calculus NOS
42040 GP clinical event records 7B1C000 Extracorp shockwave lithotripsy of unspec ureteric calculus
42040 GP clinical event records 7B1C100 Extracorporeal shockwave therapy for stone in upper ureter
42040 GP clinical event records 7B1C200 Extracorporeal shockwave lithotripsy for stone in mid-ureter
42040 GP clinical event records 7B1C300 Extracorporeal shockwave lithotripsy stone in lower ureter
42040 GP clinical event records 7B1C.00 Extracorporeal shockwave lithotripsy of ureteric calculus
42040 GP clinical event records 7B1Cy00 Extracorporeal shockwave lithotripsy of ureteric calculus OS
42040 GP clinical event records 7B1Cz00 Extracorporeal shockwave lithotripsy ureteric calculus NOS
42040 GP clinical event records 7B1F000 Endoscopic extraction of calculus of urinary diversion
42040 GP clinical event records 7B25000 Open removal of bladder calculus
42040 GP clinical event records 7B29100 Other endoscopic extraction of bladder calculus
42040 GP clinical event records 7B29400 Electrokinetic lithotripsy of bladder calculus
42040 GP clinical event records 7B2B400 Removal of bladder calculus by urethral catheter suction
42040 GP clinical event records 7B42300 Open urethrotomy and removal of calculus
42040 GP clinical event records 7B42400 Open extraction of calculus from urethra
42040 GP clinical event records 7B43900 Endoscopic removal of urethral calculus
42040 GP clinical event records C341100 Uric acid nephrolithiasis
42040 GP clinical event records C341111 Renal stone - uric acid
42040 GP clinical event records K100600 Calculous pyelonephritis
42040 GP clinical event records K112.00 Hydronephrosis with renal and ureteral calculous obstruction
42040 GP clinical event records K120000 Staghorn calculus
42040 GP clinical event records K120.00 Calculus of kidney
42040 GP clinical event records K120.11 Nephrolithiasis NOS
42040 GP clinical event records K120.12 Renal calculus
42040 GP clinical event records K120.13 Renal stone
42040 GP clinical event records K120z00 Renal calculus NOS
42040 GP clinical event records K121.00 Calculus of ureter
42040 GP clinical event records K121.11 Ureteric calculus
42040 GP clinical event records K121.12 Ureteric stone
42040 GP clinical event records K121.13 Ureterolithiasis
42040 GP clinical event records K122.00 Calculus of kidney with calculus of ureter
42040 GP clinical event records K12..00 Calculus of kidney and ureter
42040 GP clinical event records K12..11 Kidney calculus
42040 GP clinical event records K12..12 Urinary calculus
42040 GP clinical event records K12z.00 Urinary calculus NOS
42040 GP clinical event records K140000 Calculus in diverticulum of bladder
42040 GP clinical event records K140100 Other calculus in bladder
42040 GP clinical event records K140.00 Bladder calculus
42040 GP clinical event records K140.11 Bladder stone
42040 GP clinical event records K140z00 Bladder calculus NOS
42040 GP clinical event records K141.00 Calculus in urethra
42040 GP clinical event records K14..00 Lower urinary tract calculus
42040 GP clinical event records K14y.00 Other lower urinary tract calculus
42040 GP clinical event records K14z.00 Lower urinary tract calculus NOS
42040 GP clinical event records K1A..00 Urinary calculus in schistosomiasis
42040 GP clinical event records Kyu3000 [X]Other lower urinary tract calculus
42040 GP clinical event records Kyu3100 [X]Calculus of urinary tract in other diseases CE
42040 GP clinical event records Kyu3.00 [X]Urolithiasis
42040 GP clinical event records R080000 [D]Renal colic, unspecified
42040 GP clinical event records R080100 [D]Ureteric colic
42040 GP clinical event records R080.00 [D]Renal colic
42040 GP clinical event records R080z00 [D]Renal colic NOS
42040 GP clinical event records XE26R O/E - vesical oxalate calculus
42040 GP clinical event records XaC0P Electrokinetic lithotripsy of bladder calculus
42040 GP clinical event records XE0dj Calculus of kidney and ureter
42040 GP clinical event records XaIlz Endoscopic extraction of calculus of kidney nec
42040 GP clinical event records XE26Q O/E: phosphate -staghorn-stone
42040 GP clinical event records XE26S O/E-vesical uric acid calculus
42040 GP clinical event records XaMBE Open extraction of calculus from urethra
42040 GP clinical event records XE0G8 Cystoscopic extraction of ureteric calculus
42040 GP clinical event records XE26T O/E-vesical phosphate calculus
42040 GP clinical event records XE0rV Renal colic
42040 GP clinical event records XE0rV Renal colic
42040 GP clinical event records XE0dk Calculus of kidney
42040 GP clinical event records XaFzI Endoscopic removal of urethral calculus
42040 GP clinical event records XaMtc Endoscopic extraction of calculus of urinary diversion