Metadata
| Name | Urticaria (urticaria) |
| Category | Skin |
| Sex | |
| Adult | Yes |
| UUID | b60045a5-77ff-4728-9d2c-d5b42646a2ad |
| Definition | A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress. |
Ontologies
| Disease Ontology (DOID) | DOID_1555 |
| GWAS Catalogue | EFO_0005531 |
| MeSH | D014581 |
| SNOMED-CT | 126485001 |
| FinnGen | L12_URTICARIA |
Key Summary Statistics
Cases from any source
| Total | 11123 |
| Female (%) | 7496 (67%) |
| Male (%) | 3627 (33%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 371.43 (358.71,384.16) |
| Male | 206.49 (196.06,216.92) |
Incidence stratified by sex
| Female | 22.68 (21.41,23.94) |
| Male | 13.84 (12.77,14.91) |
Incidence stratified by age
| Ages 40-44 | 18.39 (15.68,21.1) |
| Ages 45-49 | 18.24 (15.92,20.56) |
| Ages 50-54 | 17.77 (15.65,19.88) |
| Ages 55-59 | 19.05 (17.06,21.03) |
| Ages 60-64 | 19.18 (17.47,20.9) |
| Ages 65-69 | 18.47 (16.55,20.39) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 398 (380,418) | 409 (394,425) | 422 (409,436) |
| CALIBER | 489 (483,494) | 509 (503,516) | 517 (509,524) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 406(361,454) | 421(387,457) | 463(434,494) |
| Low | 410(365,459) | 413(379,449) | 418(390,448) |
| Medium | 395(352,441) | 415(381,451) | 416(387,446) |
| High | 362(324,403) | 400(368,435) | 422(392,454) |
| Most deprived | 421(382,462) | 398(366,433) | 384(354,415) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 419(397,441) | 432(415,450) | 442(427,457) |
| Scotland | 191(155,232) | 238(207,271) | 211(185,240) |
| Wales | 527(449,615) | 472(416,533) | 548(495,606) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153595, Events=126
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.75 (0.51, 1.1) | 0.143 |
| BMI | obese | 0.53 (0.31, 0.88) | 0.014 |
| BMI | underweight | 0 (0, Inf) | 0.992 |
| smoking | previous | 1.05 (0.71, 1.56) | 0.804 |
| smoking | current | 1.31 (0.76, 2.25) | 0.339 |
| hypertension | yes | 1.64 (1.09, 2.47) | 0.0186 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1563 | urticaria |
| 41202 | Diagnoses - main ICD10 | L50 | Urticaria |
| 41204 | Diagnoses - secondary ICD10 | L50 | Urticaria |
| 40001 | Underlying (primary) cause of death: ICD10 | L50 | Urticaria |
| 40002 | Contributory (secondary) causes of death: ICD10 | L50 | Urticaria |
| 42040 | GP clinical event records | 2F82.00 | O/E - weals present |
| 42040 | GP clinical event records | 2F8..00 | O/E - weals present |
| 42040 | GP clinical event records | 2F8Z.00 | O/E - weals NOS |
| 42040 | GP clinical event records | M12A200 | Solar urticaria |
| 42040 | GP clinical event records | M280.00 | Allergic urticaria |
| 42040 | GP clinical event records | M280.11 | Drug induced urticaria |
| 42040 | GP clinical event records | M281.00 | Idiopathic urticaria |
| 42040 | GP clinical event records | M282000 | Cold urticaria |
| 42040 | GP clinical event records | M282100 | Thermal urticaria |
| 42040 | GP clinical event records | M282111 | Heat urticaria |
| 42040 | GP clinical event records | M282.00 | Urticaria due to cold and heat |
| 42040 | GP clinical event records | M282z00 | Urticaria due to cold and heat NOS |
| 42040 | GP clinical event records | M283.00 | Dermatographic urticaria |
| 42040 | GP clinical event records | M283.11 | Factitial urticaria |
| 42040 | GP clinical event records | M284.00 | Vibratory urticaria |
| 42040 | GP clinical event records | M285.00 | Cholinergic urticaria |
| 42040 | GP clinical event records | M286.00 | Contact urticaria |
| 42040 | GP clinical event records | M287.00 | Physical urticaria |
| 42040 | GP clinical event records | M28..00 | Urticaria |
| 42040 | GP clinical event records | M28y000 | Urticaria geographica |
| 42040 | GP clinical event records | M28y100 | Menstrual urticaria |
| 42040 | GP clinical event records | M28y200 | Urticaria persistans |
| 42040 | GP clinical event records | M28y.00 | Other specified urticaria |
| 42040 | GP clinical event records | M28y.11 | Nettle rash |
| 42040 | GP clinical event records | M28yz00 | Other specified urticaria NOS |
| 42040 | GP clinical event records | M28z.00 | Urticaria NOS |
| 42040 | GP clinical event records | M28z.11 | Hives |
| 42040 | GP clinical event records | Myu4000 | [X]Other urticaria |
| 42040 | GP clinical event records | Myu4.00 | [X]Urticaria and erythema |
| 42040 | GP clinical event records | PH32100 | Urticaria pigmentosa |
| 42040 | GP clinical event records | XE1BT | Urticaria NOS |
| 42040 | GP clinical event records | X5050 | Solar urticaria |
| 42040 | GP clinical event records | XE1BS | Other specified urticaria |
| 42040 | GP clinical event records | X508P | Physical urticaria |
| 42040 | GP clinical event records | 2F8.. | O/E - weals present |
| 42040 | GP clinical event records | XE1BR | Allergic urticaria |