Urinary Tract Infections

Metadata

Name	Urinary Tract Infections (uti)
Category	Infections
Sex
Adult	Yes
UUID	84314c54-843d-4936-9b5f-dbca0bc3ea42
Definition	Cystitis is inflammation of the bladder, usually caused by a bladder infection.

Ontologies

Disease Ontology (DOID)	DOID_1679
GWAS Catalogue	EFO_1000025
MeSH	D003556
SNOMED-CT	38822007
FinnGen	N14_CYSTITIS

Key Summary Statistics

Cases from any source

Total	30468
Female (%)	17228 (57%)
Male (%)	13240 (43%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	195.91 (186.59,205.24)
Male	135.93 (127.44,144.43)

Incidence stratified by sex

Female	29.86 (28.42,31.3)
Male	30.31 (28.73,31.89)

Incidence stratified by age

Ages 40-44	11.31 (9.21,13.42)
Ages 45-49	13.73 (11.73,15.72)
Ages 50-54	21.14 (18.85,23.44)
Ages 55-59	24.78 (22.53,27.03)
Ages 60-64	36.82 (34.46,39.18)
Ages 65-69	54.35 (51.05,57.64)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	197 (184,211)	286 (273,299)	435 (422,449)
CALIBER	185 (182,189)	257 (252,262)	479 (472,486)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	171(143,204)	253(227,282)	388(361,417)
Low	155(128,187)	225(200,253)	387(360,415)
Medium	175(147,206)	272(245,302)	399(371,429)
High	205(177,236)	277(250,306)	447(416,480)
Most deprived	255(225,287)	395(363,430)	583(546,622)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	196(181,211)	272(258,286)	421(407,437)
Scotland	221(182,265)	341(303,381)	504(462,548)
Wales	169(127,221)	333(286,386)	473(424,527)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1514	cystitis
41202	Diagnoses - main ICD10	N08.0	Glomerular disorders in infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	N10	Acute tubulo-interstitial nephritis
41202	Diagnoses - main ICD10	N13.6	Pyonephrosis
41202	Diagnoses - main ICD10	N15.1	Renal and perinephric abscess
41202	Diagnoses - main ICD10	N16.0	Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	N29.0	Late syphilis of kidney
41202	Diagnoses - main ICD10	N29.1	Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	N30.0	Acute cystitis
41202	Diagnoses - main ICD10	N30.9	Cystitis, unspecified
41202	Diagnoses - main ICD10	N33.0	Tuberculous cystitis
41202	Diagnoses - main ICD10	N34	Urethritis and urethral syndrome
41202	Diagnoses - main ICD10	N37.0	Urethritis in diseases classified elsewhere
41202	Diagnoses - main ICD10	N39.0	Urinary tract infection, site not specified
41204	Diagnoses - secondary ICD10	N08.0	Glomerular disorders in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	N10	Acute tubulo-interstitial nephritis
41204	Diagnoses - secondary ICD10	N13.6	Pyonephrosis
41204	Diagnoses - secondary ICD10	N15.1	Renal and perinephric abscess
41204	Diagnoses - secondary ICD10	N16.0	Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	N29.0	Late syphilis of kidney
41204	Diagnoses - secondary ICD10	N29.1	Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	N30.0	Acute cystitis
41204	Diagnoses - secondary ICD10	N30.9	Cystitis, unspecified
41204	Diagnoses - secondary ICD10	N33.0	Tuberculous cystitis
41204	Diagnoses - secondary ICD10	N34	Urethritis and urethral syndrome
41204	Diagnoses - secondary ICD10	N37.0	Urethritis in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	N39.0	Urinary tract infection, site not specified
40001	Underlying (primary) cause of death: ICD10	N08.0	Glomerular disorders in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	N10	Acute tubulo-interstitial nephritis
40001	Underlying (primary) cause of death: ICD10	N13.6	Pyonephrosis
40001	Underlying (primary) cause of death: ICD10	N15.1	Renal and perinephric abscess
40001	Underlying (primary) cause of death: ICD10	N16.0	Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	N29.0	Late syphilis of kidney
40001	Underlying (primary) cause of death: ICD10	N29.1	Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	N30.0	Acute cystitis
40001	Underlying (primary) cause of death: ICD10	N30.9	Cystitis, unspecified
40001	Underlying (primary) cause of death: ICD10	N33.0	Tuberculous cystitis
40001	Underlying (primary) cause of death: ICD10	N34	Urethritis and urethral syndrome
40001	Underlying (primary) cause of death: ICD10	N37.0	Urethritis in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	N39.0	Urinary tract infection, site not specified
40002	Contributory (secondary) causes of death: ICD10	N08.0	Glomerular disorders in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	N10	Acute tubulo-interstitial nephritis
40002	Contributory (secondary) causes of death: ICD10	N13.6	Pyonephrosis
40002	Contributory (secondary) causes of death: ICD10	N15.1	Renal and perinephric abscess
40002	Contributory (secondary) causes of death: ICD10	N16.0	Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	N29.0	Late syphilis of kidney
40002	Contributory (secondary) causes of death: ICD10	N29.1	Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	N30.0	Acute cystitis
40002	Contributory (secondary) causes of death: ICD10	N30.9	Cystitis, unspecified
40002	Contributory (secondary) causes of death: ICD10	N33.0	Tuberculous cystitis
40002	Contributory (secondary) causes of death: ICD10	N34	Urethritis and urethral syndrome
40002	Contributory (secondary) causes of death: ICD10	N37.0	Urethritis in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	N39.0	Urinary tract infection, site not specified