Oesophageal varices

Metadata

Name	Oesophageal varices (varices)
Category	Digestive
Sex
Adult	Yes
UUID	ca190803-b5b9-493f-9282-25d08a6968b4
Definition	Abnormally dilated veins of the esophagus.

Ontologies

Disease Ontology (DOID)	DOID_112
GWAS Catalogue	EFO_0009545
MeSH	D004932
SNOMED-CT	28670008
FinnGen	I9_VARICVEOES

Key Summary Statistics

Cases from any source

Total	1523
Female (%)	590 (39%)
Male (%)	933 (61%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	9.9 (7.79,12.02)
Male	9.38 (7.13,11.62)

Incidence stratified by sex

Female	1.21 (0.93,1.5)
Male	2.19 (1.77,2.61)

Incidence stratified by age

Ages 40-44	0.5 (0.06,0.94)
Ages 45-49	0.82 (0.33,1.3)
Ages 50-54	2.22 (1.48,2.95)
Ages 55-59	1.4 (0.87,1.93)
Ages 60-64	1.84 (1.32,2.37)
Ages 65-69	2.36 (1.69,3.04)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	12 (8,15)	19 (16,23)	23 (20,26)
CALIBER	14 (13,15)	25 (24,27)	30 (28,31)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	8(3,18)	10(6,18)	17(12,24)
Low	8(3,18)	12(7,20)	15(10,21)
Medium	8(3,17)	19(12,29)	22(16,30)
High	17(10,28)	25(17,35)	29(22,39)
Most deprived	14(8,23)	28(20,39)	34(25,45)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	9(6,13)	19(15,23)	19(16,23)
Scotland	23(12,40)	23(14,35)	46(34,61)
Wales	20(7,44)	21(10,38)	26(15,41)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1141	oesophageal varicies
41202	Diagnoses - main ICD10	I85	Oesophageal varices
41202	Diagnoses - main ICD10	I98.2	Oesophageal varices without bleeding in diseases classified elsewhere
41202	Diagnoses - main ICD10	I98.3	Oesophageal varices with bleeding in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	I85	Oesophageal varices
41204	Diagnoses - secondary ICD10	I98.2	Oesophageal varices without bleeding in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	I98.3	Oesophageal varices with bleeding in diseases classified elsewhere
41200	Operative procedures - main OPCS4	G10	Open operations on varices of oesophagus
41200	Operative procedures - main OPCS4	G10.1	Disconnection of azygos vein
41200	Operative procedures - main OPCS4	G10.2	Transection of oesophagus using staple gun
41200	Operative procedures - main OPCS4	G10.3	Transection of oesophagus NEC
41200	Operative procedures - main OPCS4	G10.4	Local ligation of varices of oesophagus
41200	Operative procedures - main OPCS4	G10.5	Open injection sclerotherapy to varices of oesophagus
41200	Operative procedures - main OPCS4	G10.8	Other specified open operations on varices of oesophagus
41200	Operative procedures - main OPCS4	G10.9	Unspecified open operations on varices of oesophagus
41200	Operative procedures - main OPCS4	G17.4	Endoscopic injection sclerotherapy to varices of oesophagus using rigid oesophagoscope
41200	Operative procedures - main OPCS4	G43.7	Fibreoptic endoscopic rubber band ligation of upper gastrointestinal tract varices
41210	Operative procedures - secondary OPCS4	G10	G10
41210	Operative procedures - secondary OPCS4	G10.1	G10.1
41210	Operative procedures - secondary OPCS4	G10.2	G10.2
41210	Operative procedures - secondary OPCS4	G10.3	G10.3
41210	Operative procedures - secondary OPCS4	G10.4	G10.4
41210	Operative procedures - secondary OPCS4	G10.5	G10.5
41210	Operative procedures - secondary OPCS4	G10.8	G10.8
41210	Operative procedures - secondary OPCS4	G10.9	G10.9
41210	Operative procedures - secondary OPCS4	G17.4	G17.4
41210	Operative procedures - secondary OPCS4	G43.7	G43.7
40001	Underlying (primary) cause of death: ICD10	I85	Oesophageal varices
40001	Underlying (primary) cause of death: ICD10	I98.2	Oesophageal varices without bleeding in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	I98.3	Oesophageal varices with bleeding in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	I85	Oesophageal varices
40002	Contributory (secondary) causes of death: ICD10	I98.2	Oesophageal varices without bleeding in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	I98.3	Oesophageal varices with bleeding in diseases classified elsewhere
42040	GP clinical event records	7609300.0	Local ligation of oesophageal varices
42040	GP clinical event records	7609400.0	Open injection sclerotherapy to oesophageal varices
42040	GP clinical event records	7609.00	Open operations on oesophageal varices
42040	GP clinical event records	7609y00	Other specified open operation on oesophageal varices
42040	GP clinical event records	7609y11	Tanner devascularisation for bleeding varices
42040	GP clinical event records	7609z00	Open operation on oesophageal varices NOS
42040	GP clinical event records	760C300	Fibreoptic endoscopic injection sclerotherapy oesoph varices
42040	GP clinical event records	760C500	Fibreoptic endoscopic banding of oesophageal varices
42040	GP clinical event records	760F300	Rigid oesophagoscopic injection sclerotherapy oesoph varices
42040	GP clinical event records	760F400	Rigid oesophagoscopic banding of oesophageal varices
42040	GP clinical event records	761D800	Fibreopt endoscop rubber band ligation of upper GIT varices
42040	GP clinical event records	G850.00	Oesophageal varices with bleeding
42040	GP clinical event records	G851.00	Oesophageal varices without bleeding
42040	GP clinical event records	G852000	Oesophageal varices with bleeding in diseases EC
42040	GP clinical event records	G852100	Oesophageal varices without bleeding in diseases EC
42040	GP clinical event records	G852200	Oesophageal varices in cirrhosis of the liver
42040	GP clinical event records	G852300	Oesophageal varices in alcoholic cirrhosis of the liver
42040	GP clinical event records	G852.00	Oesophageal varices in diseases EC
42040	GP clinical event records	G852z00	Oesophageal varices in diseases EC NOS
42040	GP clinical event records	G858.00	Oesophageal varices NOS
42040	GP clinical event records	G85..11	Oesophageal varices
42040	GP clinical event records	Gyu9400	[X]Oesophageal varices in diseases classified elsewhere
42040	GP clinical event records	XaE6u	Oesophageal varices NOS
42040	GP clinical event records	XE0CP	Other specified open operation on oesophageal varices
42040	GP clinical event records	XaLdJ	Fibreoptic endoscopic rubber band ligation of upper gastrointestinal tract varices
42040	GP clinical event records	XaC1d	Oesophageal varices in alcoholic cirrhosis of the liver
42040	GP clinical event records	XE0Vc	Other varicose veins
42040	GP clinical event records	XaBM6	Oesophageal varices in cirrhosis of the liver