| Name |
Vitiligo (vitiligo) |
| Category |
Skin |
| Sex |
|
| Adult |
Yes |
| UUID |
f7cfd550-e07c-4336-8fbb-ce3bc0e2f05f |
| Definition |
Generalized well-circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1194 |
| Female (%) |
691 (58%) |
| Male (%) |
503 (42%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
32.42 (28.59,36.24) |
| Male |
27.3 (23.47,31.13) |
Incidence stratified by sex
| Female |
1.2 (0.91,1.48) |
| Male |
1.58 (1.22,1.94) |
Incidence stratified by age
| Ages 40-44 |
1.41 (0.67,2.15) |
| Ages 45-49 |
1.19 (0.61,1.77) |
| Ages 50-54 |
1.59 (0.97,2.21) |
| Ages 55-59 |
1.62 (1.05,2.18) |
| Ages 60-64 |
1.35 (0.9,1.79) |
| Ages 65-69 |
1.11 (0.64,1.57) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
39 (33,45) |
37 (32,42) |
36 (33,41) |
| CALIBER |
41 (39,43) |
42 (40,44) |
43 (41,45) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
41(27,58) |
33(24,45) |
38(30,48) |
| Low |
35(23,52) |
37(28,49) |
41(33,51) |
| Medium |
40(27,57) |
34(25,46) |
38(30,48) |
| High |
48(35,65) |
41(30,53) |
34(25,44) |
| Most deprived |
30(20,42) |
38(29,50) |
30(22,40) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
39(33,47) |
38(33,44) |
39(34,43) |
| Scotland |
26(14,45) |
25(15,38) |
21(13,32) |
| Wales |
54(31,87) |
42(27,64) |
38(25,56) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153604, Events=143
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.15 (0.77, 1.72) |
0.5 |
| BMI |
obese |
1.24 (0.79, 1.94) |
0.344 |
| BMI |
underweight |
1.62 (0.22, 11.82) |
0.632 |
| smoking |
previous |
0.87 (0.6, 1.26) |
0.453 |
| smoking |
current |
1.02 (0.6, 1.75) |
0.937 |
| hypertension |
yes |
1.14 (0.77, 1.68) |
0.523 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1661 |
vitiligo |
| 41202 |
Diagnoses - main ICD10 |
L80 |
Vitiligo |
| 41204 |
Diagnoses - secondary ICD10 |
L80 |
Vitiligo |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L80 |
Vitiligo |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L80 |
Vitiligo |
| 42040 |
GP clinical event records |
F4E5311 |
Vitiligo of eyelid |
| 42040 |
GP clinical event records |
M295100 |
Vitiligo |