Venous thromboembolic disease (Excl PE)

Metadata

Name	Venous thromboembolic disease (Excl PE) (vte_ex_pe)
Category	Cardiovascular
Sex
Adult	Yes
UUID	a039e301-690c-42cc-8771-4487bbae3f26
Definition	Obstruction of a vein or veins by a blood clot in the blood stream.

Ontologies

GWAS Catalogue	EFO_0004286
MeSH	D054556
SNOMED-CT	429098002
FinnGen	I9_VTE

Key Summary Statistics

Cases from any source

Total	16465
Female (%)	8908 (54%)
Male (%)	7557 (46%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	238.11 (227.85,248.37)
Male	196.97 (186.78,207.16)

Incidence stratified by sex

Female	8.59 (7.82,9.37)
Male	13.21 (12.17,14.26)

Incidence stratified by age

Ages 40-44	3.97 (2.72,5.21)
Ages 45-49	7.06 (5.63,8.48)
Ages 50-54	7.22 (5.89,8.56)
Ages 55-59	10.31 (8.86,11.76)
Ages 60-64	12.82 (11.42,14.21)
Ages 65-69	17.07 (15.22,18.91)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	93 (84,102)	146 (137,156)	233 (224,244)
CALIBER	107 (104,110)	166 (162,170)	276 (271,281)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	66(49,88)	123(104,144)	222(201,244)
Low	87(67,111)	127(108,149)	215(195,237)
Medium	85(65,108)	156(135,179)	225(204,248)
High	83(65,104)	164(143,188)	227(205,251)
Most deprived	129(108,153)	160(139,183)	284(259,312)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	97(86,108)	148(137,159)	239(228,250)
Scotland	49(31,72)	110(89,134)	168(144,195)
Wales	120(84,165)	191(154,233)	278(240,321)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153979, Events=141

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.41 (0.92, 2.17)	0.113
BMI	obese	1.52 (0.95, 2.43)	0.0832
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	0.89 (0.63, 1.27)	0.531
smoking	current	0.83 (0.44, 1.56)	0.561
hypertension	yes	1.5 (1.06, 2.12)	0.0207

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1068	venous thromboembolic disease
20002	Non-cancer illness code, self-reported	1094	deep venous thrombosis (dvt)
41202	Diagnoses - main ICD10	I80.1	Phlebitis and thrombophlebitis of femoral vein
41202	Diagnoses - main ICD10	I80.2	Phlebitis and thrombophlebitis of other deep vessels of lower extremities
41202	Diagnoses - main ICD10	I63.6	Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
41202	Diagnoses - main ICD10	I67.6	Nonpyogenic thrombosis of intracranial venous system
41202	Diagnoses - main ICD10	I81	Portal vein thrombosis
41202	Diagnoses - main ICD10	I82.0	Budd-Chiari syndrome
41202	Diagnoses - main ICD10	I82.2	Embolism and thrombosis of vena cava
41202	Diagnoses - main ICD10	I82.3	Embolism and thrombosis of renal vein
41204	Diagnoses - secondary ICD10	I80.1	Phlebitis and thrombophlebitis of femoral vein
41204	Diagnoses - secondary ICD10	I80.2	Phlebitis and thrombophlebitis of other deep vessels of lower extremities
41204	Diagnoses - secondary ICD10	I63.6	Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
41204	Diagnoses - secondary ICD10	I67.6	Nonpyogenic thrombosis of intracranial venous system
41204	Diagnoses - secondary ICD10	I81	Portal vein thrombosis
41204	Diagnoses - secondary ICD10	I82.0	Budd-Chiari syndrome
41204	Diagnoses - secondary ICD10	I82.2	Embolism and thrombosis of vena cava
41204	Diagnoses - secondary ICD10	I82.3	Embolism and thrombosis of renal vein
40001	Underlying (primary) cause of death: ICD10	I80.1	Phlebitis and thrombophlebitis of femoral vein
40001	Underlying (primary) cause of death: ICD10	I80.2	Phlebitis and thrombophlebitis of other deep vessels of lower extremities
40001	Underlying (primary) cause of death: ICD10	I63.6	Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
40001	Underlying (primary) cause of death: ICD10	I67.6	Nonpyogenic thrombosis of intracranial venous system
40001	Underlying (primary) cause of death: ICD10	I81	Portal vein thrombosis
40001	Underlying (primary) cause of death: ICD10	I82.0	Budd-Chiari syndrome
40001	Underlying (primary) cause of death: ICD10	I82.2	Embolism and thrombosis of vena cava
40001	Underlying (primary) cause of death: ICD10	I82.3	Embolism and thrombosis of renal vein
40002	Contributory (secondary) causes of death: ICD10	I80.1	Phlebitis and thrombophlebitis of femoral vein
40002	Contributory (secondary) causes of death: ICD10	I80.2	Phlebitis and thrombophlebitis of other deep vessels of lower extremities
40002	Contributory (secondary) causes of death: ICD10	I63.6	Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
40002	Contributory (secondary) causes of death: ICD10	I67.6	Nonpyogenic thrombosis of intracranial venous system
40002	Contributory (secondary) causes of death: ICD10	I81	Portal vein thrombosis
40002	Contributory (secondary) causes of death: ICD10	I82.0	Budd-Chiari syndrome
40002	Contributory (secondary) causes of death: ICD10	I82.2	Embolism and thrombosis of vena cava
40002	Contributory (secondary) causes of death: ICD10	I82.3	Embolism and thrombosis of renal vein
42040	GP clinical event records	14A8100	H/O: Deep Vein Thrombosis
42040	GP clinical event records	8CMWA00	On deep vein thrombosis care pathway
42040	GP clinical event records	9kg0.00	DVT stage 1 service level - enhanced services administration
42040	GP clinical event records	9kg..00	Deep vein thrombosis - enhanced services administration
42040	GP clinical event records	9kg0.11	DVT enhanced services administration stage 1 service level
42040	GP clinical event records	9kg1.00	DVT stage 2 service level - enhanced services administration
42040	GP clinical event records	9kg2.00	DVT stage 3 service level - enhanced services administration
42040	GP clinical event records	F050000	Embolism cavernous sinus
42040	GP clinical event records	F050.00	Embolism of central nervous system venous sinus
42040	GP clinical event records	F05..00	Phlebitis and thrombophlebitis of intracranial sinuses
42040	GP clinical event records	F050100	Embolism superior longitudinal sinus
42040	GP clinical event records	F050300	Embolism transverse sinus
42040	GP clinical event records	F051000	Thrombosis cavernous sinus
42040	GP clinical event records	F051.00	Thrombosis of central nervous system venous sinuses
42040	GP clinical event records	F051100	Thrombosis of superior longitudinal sinus
42040	GP clinical event records	F051200	Thrombosis lateral sinus
42040	GP clinical event records	F051300	Thrombosis transverse sinus
42040	GP clinical event records	F051z00	Thrombosis of central nervous system venous sinus NOS
42040	GP clinical event records	F053000	Thrombophlebitis of cavernous sinus
42040	GP clinical event records	F053.00	Thrombophlebitis of central nervous system venous sinuses
42040	GP clinical event records	F053100	Thrombophlebitis of superior longitudinal venous sinus
42040	GP clinical event records	F05z.00	Phlebitis or thrombophlebitis of CNS venous sinus NOS
42040	GP clinical event records	G676000	Cereb infarct due cerebral venous thrombosis, nonpyogenic
42040	GP clinical event records	G676.00	Nonpyogenic venous sinus thrombosis
42040	GP clinical event records	G67A.00	Cerebral vein thrombosis
42040	GP clinical event records	G801.00	Deep vein phlebitis and thrombophlebitis of the leg
42040	GP clinical event records	G801.11	Deep vein thrombosis
42040	GP clinical event records	G801.12	Deep vein thrombosis, leg
42040	GP clinical event records	G801.13	DVT - Deep vein thrombosis
42040	GP clinical event records	G801600	Thrombophlebitis of the femoral vein
42040	GP clinical event records	G801700	Thrombophlebitis of the popliteal vein
42040	GP clinical event records	G801800	Thrombophlebitis of the anterior tibial vein
42040	GP clinical event records	G801900	Thrombophlebitis of the dorsalis pedis vein
42040	GP clinical event records	G801A00	Thrombophlebitis of the posterior tibial vein
42040	GP clinical event records	G801B00	Deep vein thrombophlebitis of the leg unspecified
42040	GP clinical event records	G801C00	Deep vein thrombosis of leg related to air travel
42040	GP clinical event records	G801D00	Deep vein thrombosis of lower limb
42040	GP clinical event records	G801E00	Deep vein thrombosis of leg related to intravenous drug use
42040	GP clinical event records	G801F00	Deep vein thrombosis of peroneal vein
42040	GP clinical event records	G801G00	Recurrent deep vein thrombosis
42040	GP clinical event records	G801z00	Deep vein phlebitis and thrombophlebitis of the leg NOS
42040	GP clinical event records	G80y.11	Phlebitis and/or thrombophlebitis of iliac vein
42040	GP clinical event records	G80y400	Thrombophlebitis of the common iliac vein
42040	GP clinical event records	G80y500	Thrombophlebitis of the internal iliac vein
42040	GP clinical event records	G80y600	Thrombophlebitis of the external iliac vein
42040	GP clinical event records	G80y700	Thrombophlebitis of the iliac vein unspecified
42040	GP clinical event records	G80y800	Phlebitis and thrombophlebitis of the iliac vein NOS
42040	GP clinical event records	G81..00	Portal vein thrombosis
42040	GP clinical event records	G820.00	Budd - Chiari syndrome (hepatic vein thrombosis)
42040	GP clinical event records	G820.11	Hepatic vein thrombosis
42040	GP clinical event records	G822000	Thrombosis of inferior vena cava
42040	GP clinical event records	G822.00	Embolism and thrombosis of the vena cava
42040	GP clinical event records	G823.00	Embolism and thrombosis of the renal vein
42040	GP clinical event records	G824.00	Axillary vein thrombosis
42040	GP clinical event records	G825.00	Thrombosis of subclavian vein
42040	GP clinical event records	G826.00	Thrombosis of internal jugular vein
42040	GP clinical event records	G827.00	Thrombosis of external jugular vein
42040	GP clinical event records	Gyu8000	[X]Phlebitis+thrombophlebitis/oth deep vessls/low extremites
42040	GP clinical event records	J420200	Thrombus of the superior mesenteric veins
42040	GP clinical event records	SP12200	Post operative deep vein thrombosis
42040	GP clinical event records	ZV12800	[V] Personal history deep vein thrombosis
42040	GP clinical event records	ZV12811	[V] Personal history DVT- deep vein thrombosis
42040	GP clinical event records	XaIIo	Deep vein thrombosis of leg related to air travel
42040	GP clinical event records	Xa9Bs	Deep vein thrombosis of lower limb
42040	GP clinical event records	XaZht	Thrombosis of subclavian vein
42040	GP clinical event records	XaaBG	On deep vein thrombosis care pathway
42040	GP clinical event records	Xa6Yt	Cerebral vein thrombosis
42040	GP clinical event records	Xaa2L	Thrombosis of external jugular vein
42040	GP clinical event records	XaBMc	[V] Personal history deep vein thrombosis
42040	GP clinical event records	XE0VZ	Other phlebitis and thrombophlebitis
42040	GP clinical event records	Xa1oU	Thrombosis of inferior vena cava
42040	GP clinical event records	XaZ43	Recurrent deep vein thrombosis
42040	GP clinical event records	Xa6Yr	Axillary vein thrombosis
42040	GP clinical event records	XaJxo	Deep vein thrombosis of leg related to intravenous drug use
42040	GP clinical event records	XE0VY	Deep vein phlebitis and thrombophlebitis of the leg
42040	GP clinical event records	Xaa2K	Thrombosis of internal jugular vein